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Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol
Li, Xinru; Zhang, Yanhui; Fan, Yating; Zhou, Yanxia; Wang, Xiaoning; Fan, Chao; Liu, Yan; Zhang, Qiang
刊名NANOSCALE RESEARCH LETTERS
2011
DOI10.1186/1556-276X-6-275
6
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]POLYMERIC MICELLES ; DIBLOCK COPOLYMERS ; DRUG CARRIERS ; ANESTHETIC PROPERTIES ; ANTICANCER DRUG ; IN-VITRO ; CAMPTOTHECIN ; WATER ; SOLUBILIZATION ; COMPATIBILITY
英文摘要

Novel mixed polymeric micelles formed from biocompatible polymers, poly(ethylene glycol)-poly(lactide) (mPEG-PLA) and polyoxyethylene-660-12-hydroxy stearate (Solutol HS15), were fabricated and used as a nanocarrier for solubilizing poorly soluble anesthetic drug propofol. The solubilization of propofol by the mixed micelles was more efficient than those made of mPEG-PLA alone. Micelles with the optimized composition of mPEG-PLA/Solutol HS15/propofol = 10/1/5 by weight had particle size of about 101 nm with narrow distribution (polydispersity index of about 0.12). Stability analysis of the mixed micelles in bovine serum albumin (BSA) solution indicated that the diblock copolymer mPEG efficiently protected the BSA adsorption on the mixed micelles because the hydrophobic groups of the copolymer were efficiently screened by mPEG, and propofol-loaded mixed micelles were stable upon storage for at least 6 months. The content of free propofol in the aqueous phase for mixed micelles was lower by 74% than that for the commercial lipid emulsion. No significant differences in times to unconsciousness and recovery of righting reflex were observed between mixed micelles and commercial lipid formulation. The pharmacological effect may serve as pharmaceutical nanocarriers with improved solubilization capacity for poorly soluble drugs.

语种英语
WOS记录号WOS:000290525700150
项目编号2009zx09310-001 ; 2009CB930300
资助机构National Development of Significant New Drugs (New Preparation and New Technology) ; National Basic Research Program of China (973 program)
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53350
专题北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100191, Peoples R China
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GB/T 7714
Li, Xinru,Zhang, Yanhui,Fan, Yating,et al. Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol[J]. NANOSCALE RESEARCH LETTERS,2011,6.
APA Li, Xinru.,Zhang, Yanhui.,Fan, Yating.,Zhou, Yanxia.,Wang, Xiaoning.,...&Zhang, Qiang.(2011).Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol.NANOSCALE RESEARCH LETTERS,6.
MLA Li, Xinru,et al."Preparation and evaluation of novel mixed micelles as nanocarriers for intravenous delivery of propofol".NANOSCALE RESEARCH LETTERS 6(2011).
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