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学科主题: 基础医学
题名:
Inhibitory effect of atriopeptinergic neurons in AV3V region on angiotensinII pressor system in rat brain
作者: Ku, YH; Li, YH
关键词: anteroventral third ventricle region ; lateral hypothalamus/perifonical region ; subfornical organ ; atrial natriuretic peptide ; blood pressure
刊名: PEPTIDES
发表日期: 2004-04-01
DOI: 10.1016/j.peptides.2004.02.021
卷: 25, 期:4, 页:615-620
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]: Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]: ACETYLCHOLINESTERASE-CONTAINING NEURONS ; SPONTANEOUSLY HYPERTENSIVE RATS ; CORTICOTROPIN-RELEASING-FACTOR ; CENTRAL-NERVOUS-SYSTEM ; SUBFORNICAL ORGAN ; SUBSTANCE-P ; IMMUNOREACTIVE NEURONS ; TOPOGRAPHIC ATLAS ; RESPONSES ; LOCALIZATION
英文摘要:

In the central nervous system and the periphery, atrial natriuretic peptide (ANP) and angiotensinII(AngII) play important and opposite roles in regulating blood pressure and fluid electrolyte balance. Their central mechanisms are unclear. In the brain the anteroventral third ventricle region (AV3V) contains the most prominent collection of atriopeptin-like immunoreactive perikarya. Our previous studies show that: (1) AV3V stimulation by glutamate produces a fall in blood pressure; (2) there is an AngII pressor system composed of the lateral hypothalamus/perifornical region (LH/PF), subfornical organ (SFO), nucleus paraventricularis (NPV) and rostral ventrolateral medulla (RVL). The present study was to examine whether ANPergic projections from the AV3V could act on nuclei involved in the above-mentioned AngII pressor system. Here we demonstrate that: (1) Injection of atriopeptinIII into the LH/PF, SFO, NPV, or RVL induces a depressor response; whereas injection of normal saline has no effect. (2) Pre-injection of A 71915 (an atriopeptinIII antagonist) into the LH/PF, SFO, NPV, or RVL reverses the depressor response of the AV3V to glutamate (Glu). The results suggest that excitation of atriopeptinergic neurons in the AV3V by Glu produces an inhibitory effect on each nucleus in the LH/PF-SFO-NPV-RVL AngII pressor system. (C) 2004 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000222039800011
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53354
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100083, Peoples R China

Recommended Citation:
Ku, YH,Li, YH. Inhibitory effect of atriopeptinergic neurons in AV3V region on angiotensinII pressor system in rat brain[J]. PEPTIDES,2004,25(4):615-620.
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