IR@PKUHSC  > 北京大学基础医学院  > 药理学系
学科主题基础医学
Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice
Zhu, Xiao-Ling1; Chen, Alex-F.1; Lin, Zhi-Bin1
关键词Ganoderma Lucidum (Leyss. Ex Fr.) Karst. (Ling Zhi) Polysaccharide Cyclophosphamide Cytotoxicity Immunomodulation
刊名JOURNAL OF ETHNOPHARMACOLOGY
2007-05-04
DOI10.1016/j.jep.2006.11.013
111期:2页:219-226
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine
关键词[WOS]NATURAL-KILLER ; LYMPHOCYTE-PROLIFERATION ; NKT CELLS ; IMMUNE FUNCTIONS ; CYCLOPHOSPHAMIDE ; CANCER ; LEVAMISOLE ; MACROPHAGES ; ANTITUMOR ; RECOVERY
英文摘要

The present study was designed to determine in vivo efficacy of Ganoderma lucidum polysaccharides (Gl-PS) for enhancing the activity of immunological effect or cells in immunosuppressed mice. Mice were injected intraperitoneally (i.p.) once daily with low-dose (2.5 mg/kg), intermediate-dose (25 mg/kg), and high-dose (250 mg/kg) of Gl-PS, respectively, for 7 consecutive days 24 h after i.p. injection of a immunosuppressing anti-tumor agent cyclophosphamide (Cy, 300 mg/kg). In Cy-treated mice, compared to vehicle, low-dose Gl-PS accelerated recovery of bone marrow cells, red blood cells and white blood cells, as well as splenic natural killer cells and natural killer T cells, and enhanced T and B cell proliferation responses on day 8, cytotoxic T lymphocyte activity on day 5, as well as NK cell and lymphokine activated killer cell activity on days 7-9. Furthermore, it promoted phagocytosis and cytotoxicity of macrophages on day 12. The above beneficial effects induced by the low-dose Gl-PS treatment did not result in any side effects. These results demonstrate the efficacious effects of low-dose Gl-PS treatment for enhancing the activity of immunological effector cells in immunosuppressed mice, and may provide a basis for applying this herb as an efficacious adjacent immunopotentiating therapy against cancer chemotherapy-induced immunosuppression. (c) 2006 Elsevier Ireland Ltd. All Tights reserved.

语种英语
WOS记录号WOS:000246166400005
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被引频次:117[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53357
专题北京大学基础医学院_药理学系
作者单位1.Michigan State Univ, Dept Neurol, E Lansing, MI 48824 USA
2.Peking Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Pharmacol, Beijing 100083, Peoples R China
3.Michigan State Univ, Dept Pharmacol, E Lansing, MI 48824 USA
4.Michigan State Univ, Program Neurosci, E Lansing, MI 48824 USA
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GB/T 7714
Zhu, Xiao-Ling,Chen, Alex-F.,Lin, Zhi-Bin. Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice[J]. JOURNAL OF ETHNOPHARMACOLOGY,2007,111(2):219-226.
APA Zhu, Xiao-Ling,Chen, Alex-F.,&Lin, Zhi-Bin.(2007).Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice.JOURNAL OF ETHNOPHARMACOLOGY,111(2),219-226.
MLA Zhu, Xiao-Ling,et al."Ganoderma lucidum polysaccharides enhance the function of immunological effector cells in immunosuppressed mice".JOURNAL OF ETHNOPHARMACOLOGY 111.2(2007):219-226.
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