IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer
Li, Yan; Yang, Ying; Lu, Ming; Shen, Lin
关键词Recurrence Gastric Cancer Resection
刊名HEPATO-GASTROENTEROLOGY
2011-11-01
DOI10.5754/hge11753
58期:112页:2166-2170
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]COLORECTAL-CANCER ; CARCINOEMBRYONIC ANTIGEN ; PROGNOSTIC VALUE ; FOLLOW-UP ; ADENOCARCINOMA ; SURVIVAL ; CA-19-9 ; CA-72-4 ; MARKER ; TPA
英文摘要

Background/Aims: To explore the predictive value of markers in detection of recurrence after resection. Methodology: This study was a case-control retrospective analysis; 521 patients underwent radical gastrectomy from April 2000 to January 2008, among whom 142 cases with complete data were involved. Seventy one were confirmed with recurrence, while the other 71 without recurrence were randomly selected from the database as control. We analyzed the popular serum marker change patterns and their correlation with imaging. Results: The two groups were well balanced in characteristics. Among the 3 markers, CA72.4 appeared highest in sensitivity (35.2%) while CEA had the lowest sensitivity. The sensitivity of triple-marker was 62.0%. We found that CEA, CA19-9 and CA72.4 elevated 2-4 months before imaging demonstration. If the cutoff values of CEA and CA19-9 were set twice as the upper limit of the normal, the specificities will increase to 98.6% and 94.4%, respectively. The sensitivity of single marker (CEA or CA 2.4) was 33.3% in predicting peritoneal metastasis, triple-marker had the highest sensitivity (66.7%). Conclusions: The combined of CEA, CA19-9 and CA72.4 had 62.0% sensitivity in the diagnosis of recurrence after radical surgery Patients whose tumor markers continue to increase should be highly suspected for relapse.

语种英语
WOS记录号WOS:000300532700071
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53359
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_消化肿瘤内科
作者单位Peking Univ, Sch Oncol, Minist Educ,Beijing Canc Hosp & Inst, Dept GI Oncol,Key Lab Carcinogenesis & Translat R, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Li, Yan,Yang, Ying,Lu, Ming,et al. Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer[J]. HEPATO-GASTROENTEROLOGY,2011,58(112):2166-2170.
APA Li, Yan,Yang, Ying,Lu, Ming,&Shen, Lin.(2011).Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer.HEPATO-GASTROENTEROLOGY,58(112),2166-2170.
MLA Li, Yan,et al."Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer".HEPATO-GASTROENTEROLOGY 58.112(2011):2166-2170.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Li, Yan]的文章
[Yang, Ying]的文章
[Lu, Ming]的文章
百度学术
百度学术中相似的文章
[Li, Yan]的文章
[Yang, Ying]的文章
[Lu, Ming]的文章
必应学术
必应学术中相似的文章
[Li, Yan]的文章
[Yang, Ying]的文章
[Lu, Ming]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。