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学科主题: 临床医学
题名:
Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer
作者: Li, Yan; Yang, Ying; Lu, Ming; Shen, Lin
关键词: Recurrence ; Gastric cancer ; Resection
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2011-11-01
DOI: 10.5754/hge11753
卷: 58, 期:112, 页:2166-2170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: COLORECTAL-CANCER ; CARCINOEMBRYONIC ANTIGEN ; PROGNOSTIC VALUE ; FOLLOW-UP ; ADENOCARCINOMA ; SURVIVAL ; CA-19-9 ; CA-72-4 ; MARKER ; TPA
英文摘要:

Background/Aims: To explore the predictive value of markers in detection of recurrence after resection. Methodology: This study was a case-control retrospective analysis; 521 patients underwent radical gastrectomy from April 2000 to January 2008, among whom 142 cases with complete data were involved. Seventy one were confirmed with recurrence, while the other 71 without recurrence were randomly selected from the database as control. We analyzed the popular serum marker change patterns and their correlation with imaging. Results: The two groups were well balanced in characteristics. Among the 3 markers, CA72.4 appeared highest in sensitivity (35.2%) while CEA had the lowest sensitivity. The sensitivity of triple-marker was 62.0%. We found that CEA, CA19-9 and CA72.4 elevated 2-4 months before imaging demonstration. If the cutoff values of CEA and CA19-9 were set twice as the upper limit of the normal, the specificities will increase to 98.6% and 94.4%, respectively. The sensitivity of single marker (CEA or CA 2.4) was 33.3% in predicting peritoneal metastasis, triple-marker had the highest sensitivity (66.7%). Conclusions: The combined of CEA, CA19-9 and CA72.4 had 62.0% sensitivity in the diagnosis of recurrence after radical surgery Patients whose tumor markers continue to increase should be highly suspected for relapse.

语种: 英语
WOS记录号: WOS:000300532700071
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53359
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: Peking Univ, Sch Oncol, Minist Educ,Beijing Canc Hosp & Inst, Dept GI Oncol,Key Lab Carcinogenesis & Translat R, Beijing 100142, Peoples R China

Recommended Citation:
Li, Yan,Yang, Ying,Lu, Ming,et al. Predictive Value of Serum CEA, CA19-9 and CA72.4 in Early Diagnosis of Recurrence after Radical Resection of Gastric Cancer[J]. HEPATO-GASTROENTEROLOGY,2011,58(112):2166-2170.
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