|Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest|
|Tang, Zi-Ren1; Li, Chun-Sheng1; Zhao, Hong1; Gong, Ping1; Zhang, Ming-Yue1; Su, Zhi-Yu2; Wang, Shuo1|
|刊名||AMERICAN JOURNAL OF EMERGENCY MEDICINE|
|WOS标题词||Science & Technology|
|关键词[WOS]||INTERNATIONAL LIAISON COMMITTEE ; EMERGENCY CARDIOVASCULAR CARE ; MILD THERAPEUTIC HYPOTHERMIA ; GLOBAL CEREBRAL ANOXIA ; SUPPORT TASK-FORCE ; MR-SPECTROSCOPY ; COMATOSE SURVIVORS ; CLINICAL-APPLICATIONS ; ADVISORY STATEMENT ; ACUTE STROKE|
Objective: To evaluate the effects of hypothermia on cerebral edema and metabolism, a porcine model of cardiac arrest was assessed by magnetic resonance imaging during the first 72 hours after restoration of spontaneous circulation (ROSC).
Methods: Ventricular fibrillation was induced in 33 pigs. After 8 minutes of untreated ventricular fibrillation, 30: 2 cardiopulmonary resuscitation was performed. After ROSC, 30 survival animals were randomly divided into normothermia group (n=15) and hypothermia group (n=15). The hypothermia group immediately received endovascular cooling to regulate temperature to 33 degrees C, which was maintained for 12 hours, followed by passive rewarming at 0.5 degrees C/h to 37 degrees C. Diffusion-weighted imaging and (1)hydrogen proton magnetic resonance spectroscopy were acquired for each group at 6, 12, 24, and 72 hours after ROSC.
Results: Compared with the normothermia group, the hypothermia group exhibited a higher 72-hour survival (73.3% vs. 33.3%, P=.028) and a superior neurological deficit score (P=.031). Cerebral injury was found in both groups, but a lesser decrease in the apparent diffusion coefficient and N-acetyl aspartate/creatinine (P<.05) and a greater increase in choline/creatinine (P<.05) were found in the hypothermia group.
Conclusions: Magnetic resonance imaging could effectively detect the dynamic trend of cerebral injury in a porcine model of cardiac arrest within the first 72 hours after ROSC. Hypothermia produced a protective effect on neurological function by reducing brain edema and formation of adverse metabolites. (C) 2013 Elsevier Inc. All rights reserved.
|资助机构||National Science Foundation of China|
|作者单位||1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Emergency Med, Beijing 100020, Peoples R China|
2.Peking Univ, Peoples Hosp, Dept Emergency Med, Beijing 100871, Peoples R China
|Tang, Zi-Ren,Li, Chun-Sheng,Zhao, Hong,et al. Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest[J]. AMERICAN JOURNAL OF EMERGENCY MEDICINE,2013,31(1):86-93.|
|APA||Tang, Zi-Ren.,Li, Chun-Sheng.,Zhao, Hong.,Gong, Ping.,Zhang, Ming-Yue.,...&Wang, Shuo.(2013).Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest.AMERICAN JOURNAL OF EMERGENCY MEDICINE,31(1),86-93.|
|MLA||Tang, Zi-Ren,et al."Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest".AMERICAN JOURNAL OF EMERGENCY MEDICINE 31.1(2013):86-93.|