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学科主题: 临床医学
题名:
Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest
作者: Tang, Zi-Ren1; Li, Chun-Sheng1; Zhao, Hong1; Gong, Ping1; Zhang, Ming-Yue1; Su, Zhi-Yu2; Wang, Shuo1
刊名: AMERICAN JOURNAL OF EMERGENCY MEDICINE
发表日期: 2013
DOI: 10.1016/j.ajem.2012.06.008
卷: 31, 期:1, 页:86-93
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Emergency Medicine
研究领域[WOS]: Emergency Medicine
关键词[WOS]: INTERNATIONAL LIAISON COMMITTEE ; EMERGENCY CARDIOVASCULAR CARE ; MILD THERAPEUTIC HYPOTHERMIA ; GLOBAL CEREBRAL ANOXIA ; SUPPORT TASK-FORCE ; MR-SPECTROSCOPY ; COMATOSE SURVIVORS ; CLINICAL-APPLICATIONS ; ADVISORY STATEMENT ; ACUTE STROKE
英文摘要:

Objective: To evaluate the effects of hypothermia on cerebral edema and metabolism, a porcine model of cardiac arrest was assessed by magnetic resonance imaging during the first 72 hours after restoration of spontaneous circulation (ROSC).

Methods: Ventricular fibrillation was induced in 33 pigs. After 8 minutes of untreated ventricular fibrillation, 30: 2 cardiopulmonary resuscitation was performed. After ROSC, 30 survival animals were randomly divided into normothermia group (n=15) and hypothermia group (n=15). The hypothermia group immediately received endovascular cooling to regulate temperature to 33 degrees C, which was maintained for 12 hours, followed by passive rewarming at 0.5 degrees C/h to 37 degrees C. Diffusion-weighted imaging and (1)hydrogen proton magnetic resonance spectroscopy were acquired for each group at 6, 12, 24, and 72 hours after ROSC.

Results: Compared with the normothermia group, the hypothermia group exhibited a higher 72-hour survival (73.3% vs. 33.3%, P=.028) and a superior neurological deficit score (P=.031). Cerebral injury was found in both groups, but a lesser decrease in the apparent diffusion coefficient and N-acetyl aspartate/creatinine (P<.05) and a greater increase in choline/creatinine (P<.05) were found in the hypothermia group.

Conclusions: Magnetic resonance imaging could effectively detect the dynamic trend of cerebral injury in a porcine model of cardiac arrest within the first 72 hours after ROSC. Hypothermia produced a protective effect on neurological function by reducing brain edema and formation of adverse metabolites. (C) 2013 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30972863
项目资助者: National Science Foundation of China
WOS记录号: WOS:000312954600014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53363
Appears in Collections:北京大学第二临床医学院_急诊科_期刊论文

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作者单位: 1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Emergency Med, Beijing 100020, Peoples R China
2.Peking Univ, Peoples Hosp, Dept Emergency Med, Beijing 100871, Peoples R China

Recommended Citation:
Tang, Zi-Ren,Li, Chun-Sheng,Zhao, Hong,et al. Effects of hypothermia on brain injury assessed by magnetic resonance imaging after cardiopulmonary resuscitation in a porcine model of cardiac arrest[J]. AMERICAN JOURNAL OF EMERGENCY MEDICINE,2013,31(1):86-93.
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