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学科主题: 临床医学
题名:
Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect
作者: Huang, X-J; Wang, Y.; Liu, D-H; Xu, L-P; Liu, K-Y; Chen, H.; Chen, Y-H; Han, W.; Shi, H-X
关键词: donor lymphocytes infusion ; relapse ; GVHD ; transplantation
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2009-09-01
DOI: 10.1038/bmt.2009.26
卷: 44, 期:5, 页:309-316
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; LEUKEMIA-WORKING-PARTY ; ACUTE MYELOID-LEUKEMIA ; HEMATOLOGIC MALIGNANCIES ; LEUKOCYTE INFUSIONS ; RELAPSE
英文摘要:

Donor lymphocyte infusion (DLI) exerts a GVL effect, but its use is limited by a high incidence of GVHD. We retrospectively evaluated the efficacy of administering short-term immunosuppressive agents for prophylaxis against DLI-associated acute GVHD, and its influence on the GVL effect. Seventy patients with leukaemia received G-CSF primed DLI after HLA-identical sibling haematopoietic stem cell transplantation (HSCT) for treatment or prophylaxis against leukaemia relapse. Short-term immunosuppressive agents were given to 54 patients for prophylaxis against DLI-associated acute GVHD. Seventeen patients experienced acute GVHD; 30 patients developed chronic GVHD; and no GVHD-related death was observed. A significant difference was observed between the group that did not receive prophylaxis against GVHD or received prophylaxis for less than 2 weeks and the group that received prophylaxis for over 2 weeks (CsA or MTX at 10 mg/week) with regard to the incidence of DLI-associated acute GVHD (14/28 vs 3/42, P = 0.000); no difference was observed in the relapse rate for prophylactic DLI patients between the two groups (4/10 vs 12/29). Using immunosuppressive agents for 2-4 weeks may reduce DLI-associated acute GVHD without influencing relapse and survival after G-CSF-primed DLI. Bone Marrow Transplantation (2009) 44, 309-316; doi: 10.1038/bmt.2009.26; published online 23 February 2009

语种: 英语
所属项目编号: 30725038 ; 2006AA02Z4A0 ; IRT 0702 ; 2006-1010
项目资助者: National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-tech Research and Development Program of China ; Program for Innovative Research Team in University ; Scientific Research Fund for Capital Medicine Development ; Ministry of Health of China
WOS记录号: WOS:000269674000006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53364
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Huang, X-J,Wang, Y.,Liu, D-H,et al. Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect[J]. BONE MARROW TRANSPLANTATION,2009,44(5):309-316.
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