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Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect
Huang, X-J; Wang, Y.; Liu, D-H; Xu, L-P; Liu, K-Y; Chen, H.; Chen, Y-H; Han, W.; Shi, H-X
关键词Donor Lymphocytes Infusion Relapse Gvhd Transplantation
刊名BONE MARROW TRANSPLANTATION
2009-09-01
DOI10.1038/bmt.2009.26
44期:5页:309-316
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; DONOR LYMPHOCYTE INFUSION ; COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; LEUKEMIA-WORKING-PARTY ; ACUTE MYELOID-LEUKEMIA ; HEMATOLOGIC MALIGNANCIES ; LEUKOCYTE INFUSIONS ; RELAPSE
英文摘要

Donor lymphocyte infusion (DLI) exerts a GVL effect, but its use is limited by a high incidence of GVHD. We retrospectively evaluated the efficacy of administering short-term immunosuppressive agents for prophylaxis against DLI-associated acute GVHD, and its influence on the GVL effect. Seventy patients with leukaemia received G-CSF primed DLI after HLA-identical sibling haematopoietic stem cell transplantation (HSCT) for treatment or prophylaxis against leukaemia relapse. Short-term immunosuppressive agents were given to 54 patients for prophylaxis against DLI-associated acute GVHD. Seventeen patients experienced acute GVHD; 30 patients developed chronic GVHD; and no GVHD-related death was observed. A significant difference was observed between the group that did not receive prophylaxis against GVHD or received prophylaxis for less than 2 weeks and the group that received prophylaxis for over 2 weeks (CsA or MTX at 10 mg/week) with regard to the incidence of DLI-associated acute GVHD (14/28 vs 3/42, P = 0.000); no difference was observed in the relapse rate for prophylactic DLI patients between the two groups (4/10 vs 12/29). Using immunosuppressive agents for 2-4 weeks may reduce DLI-associated acute GVHD without influencing relapse and survival after G-CSF-primed DLI. Bone Marrow Transplantation (2009) 44, 309-316; doi: 10.1038/bmt.2009.26; published online 23 February 2009

语种英语
WOS记录号WOS:000269674000006
项目编号30725038 ; 2006AA02Z4A0 ; IRT 0702 ; 2006-1010
资助机构National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-tech Research and Development Program of China ; Program for Innovative Research Team in University ; Scientific Research Fund for Capital Medicine Development ; Ministry of Health of China
引用统计
被引频次:33[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53364
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Huang, X-J,Wang, Y.,Liu, D-H,et al. Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect[J]. BONE MARROW TRANSPLANTATION,2009,44(5):309-316.
APA Huang, X-J.,Wang, Y..,Liu, D-H.,Xu, L-P.,Liu, K-Y.,...&Shi, H-X.(2009).Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect.BONE MARROW TRANSPLANTATION,44(5),309-316.
MLA Huang, X-J,et al."Administration of short-term immunosuppressive agents after DLI reduces the incidence of DLI-associated acute GVHD without influencing the GVL effect".BONE MARROW TRANSPLANTATION 44.5(2009):309-316.
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