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学科主题: 临床医学
题名:
Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats
作者: Chang, Lin1; Geng, Bin1,2; Yu, Fang2; Zhao, Jing2; Jiang, Hongfeng2; Du, Junbao3; Tang, Chaoshu1,2
关键词: homocysteine ; hydrogen sulfide ; sulfur containing amino acids ; oxidative stress ; endoplasmic reticulum stress
刊名: AMINO ACIDS
发表日期: 2008-05-01
DOI: 10.1007/s00726-007-0011-8
卷: 34, 期:4, 页:573-585
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: INDUCED OXIDATIVE STRESS ; PROGRAMMED CELL-DEATH ; CARDIOVASCULAR-DISEASE ; ENDOTHELIAL DYSFUNCTION ; MITOCHONDRIAL-FUNCTION ; SUPEROXIDE-DISMUTASE ; RESPIRATORY-FUNCTION ; OXIDASE INHIBITION ; CARDIAC-MUSCLE ; FOLIC-ACID
英文摘要:

Hyperhomocysteinemia (HHcy) is a critical independent risk factor for cardiovascular diseases. However, to date, no satisfactory strategies to prevent HHcy exist. Since homocysteine (Hcy) and endogenous H2S are both metabolites of sulfur-containing amino acids, we aimed to investigate whether a metabolic product of Hcy and H2S, may antagonize in part the cardiovascular effects of Hcy. In the HHcy rat model injected subcutaneously with Hcy for 3 weeks, H2S levels and the H2S-generating enzyme cystathionine gamma lyase (CSE) activity in the myocardium were decreased. The intraperitoneal injection of H2S gas saturation solution significantly reduced plasma total Hcy (tHcy) concentration and decreased lipid peroxidation formation (i.e., lowered manodialdehyde and conjugated diene levels in myocardia and plasma). The activities of myocardial mitochondrial respiratory enzymes succinate dehydrogenase, cytochrome oxidase, and manganese superoxide dismutase, related to reactive oxygen species metabolism, were significantly dysfunctional in HHcy rats. The H2S administration restored the level of enzyme activities and accelerated the scavenging of H2O2 and superoxide anion generated by Hcy in isolated mitochondria. The H2S treatment also inhibited the expression of glucose-regulated protein 78, a marker of endoplasmic reticulum (ER) stress, induced by Hcy in vivo and in vitro. Thus, HHcy impaired the myocardial CSE/H2S pathway, and the administration of H2S protected the myocardium from oxidative and ER stress induced by HHcy, which suggests that an endogenous metabolic balance of sulfur-containing amino acids may be a novel strategy for treatment of HHcy.

语种: 英语
WOS记录号: WOS:000255613300009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53365
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Inst Cardiovasc Res, Beijing 100034, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Pediat, Beijing 100871, Peoples R China

Recommended Citation:
Chang, Lin,Geng, Bin,Yu, Fang,et al. Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats[J]. AMINO ACIDS,2008,34(4):573-585.
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