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学科主题: 临床医学
题名:
Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1(star)0602 status
作者: Han, F.1; Mignot, E.2; Wei, Y. C.1; Dong, S. X.1; Li, J.1; Lin, L.2; An, P.1; Wang, L. H.1; Wang, J. S.1; He, M. Z.1; Gao, H. Y.1; Li, M.1; Gao, Z. C.1; Strohl, K. P.3,4
关键词: Chemoresponsiveness ; human leukocyte antigen DQB1 ; hypercapnia ; hypoxia ; narcolepsy
刊名: EUROPEAN RESPIRATORY JOURNAL
发表日期: 2010-09-01
DOI: 10.1183/09031936.00174609
卷: 36, 期:3, 页:577-583
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: OREXIN KNOCKOUT MICE ; ONSET REM PERIODS ; RAT CAROTID-BODY ; SLEEP-APNEA ; HYPERCAPNIC CHEMOREFLEX ; DAYTIME SLEEPINESS ; HLA-DQ ; HYPOXIA ; EXPRESSION ; DISORDERS
英文摘要:

We hypothesised that hypocretin (orexin) plays a role in the determination of ventilatory chemosensitivity. 130 patients with narcolepsy-cataplexy (mean +/- SD age 20 +/- 10 yrs, 69% male) and 117 controls (22 +/- 6.9 yrs, 62% male) were recruited and tested for human leukocyte antigen (HLA)-DQB1(star)0602 status, hyperoxia hypercapnic (change in minute ventilation (Delta V′E)/carbon dioxide tension (Delta PCO2) L.min(-1.)mmHg(-1)) and hypoxic (Delta V′E /change in arterial oxygen saturation measured by probe oximetry (Delta Sp,O-2) L.min(-1) per % Sp,O-2) responsiveness, and by spirometry. Hypocretin deficiency was determined either by measures of cerebrospinal fluid hypocretin-1 (37 patients) or by positive HLA-DQB1(star)0602 status. All patients and 49% of controls underwent polysomnography and multiple sleep latency testing. Despite similar spirometric values, patients had a higher apnoea/hypopnoea index (AHI) (2.8 +/- 5.4 versus 0.8 +/- 1.6 h(-1); p=0.03) and lower minimal oxygen saturation during sleep (87%+/- 7 versus 91 +/- 4%; p=0.0002), independent of age, sex and body mass index. Patients had depressed hypoxic responsiveness (0.13 +/- 0.09 versus 0.19 +/- 0.13 L.min(-1) per % Sp,O-2; p<0.0001), independent of AHI, but hypercapnic responsiveness did not differ. Examined by HLA status, positive (26 out of 117) controls had lower hypoxic but similar hypercapnic responsiveness than those marker-negative (0.13 +/- 0.08 versus 0.20 +/- 0.14 L.min(-1) per % Sp,O-2; p<0.0001). Thus, a lower hypoxic responsiveness in the narcolepsy-cataplexy group is a result of DQB1(star)0602 status rather than the clinical features of disease.

语种: 英语
所属项目编号: C30770938 ; C30300120 ; 985-2-084-113 ; NIH 23734
项目资助者: National Natural Science Foundation of China (NSFC) ; Ministry of Education China ; National Institutes of Health ; VA Research Service
WOS记录号: WOS:000282470000019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53367
Appears in Collections:北京大学第二临床医学院_呼吸内科_期刊论文

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作者单位: 1.Cleveland Louis Stokes VA Med Ctr, Cleveland, OH 44106 USA
2.Peking Univ, Peoples Hosp, Dept Pulm Med, Beijing 100871, Peoples R China
3.Stanford Univ, Howard Hughes Med Inst, Ctr Narcolepsy, Palo Alto, CA 94304 USA
4.Case Western Reserve Univ, Dept Med, Div Pulm Crit Care & Sleep Med, Cleveland, OH 44106 USA

Recommended Citation:
Han, F.,Mignot, E.,Wei, Y. C.,et al. Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1(star)0602 status[J]. EUROPEAN RESPIRATORY JOURNAL,2010,36(3):577-583.
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