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Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy
Yuan, Jie1; Wang, Lin-yuan2; Li, Jin-mei1; Cao, Ning-jia4; Wang, Liang1; Feng, Gui-bo1; Xue, Tao3; Lu, Yang1; Wang, Xue-feng1
关键词Temporal Lobe Epilepsy Rhoa Axon Growth Neuronal Loss
刊名JOURNAL OF MOLECULAR NEUROSCIENCE
2010-09-01
DOI10.1007/s12031-010-9330-4
42期:1页:53-58
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]GTPASES ; BRAIN ; PATHWAY ; REGENERATION ; INHIBITION ; SEIZURES ; Y-27632 ; CNS
英文摘要

The small guanosine triphosphatase RhoA has recently been implicated in the pathogenesis of epilepsy in animals. In this study, we investigated the expression of RhoA in human epilepsy. Brain tissue samples from 40 patients with intractable epilepsy and 14 histologically normal temporal lobes from control patients were used to compare RhoA immunoreactivity using immunohistochemistry, immunofluorescent staining, and western blotting. Immunohistochemical staining and western blot analysis showed that RhoA immunoreactivity was increased in the patient group (p<0.05). Immunofluorescent staining showed that RhoA was mainly expressed on cell membranes and in the cytoplasm. Our findings demonstrate that upregulation of RhoA immunoreactivity occurs in the brains of patients with intractable epilepsy.

语种英语
WOS记录号WOS:000280571900007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53381
专题北京大学公共卫生学院
作者单位1.Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, Chongqing 400016, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing 400010, Peoples R China
4.Shaanxi Prov Peoples Hosp, Xian 710068, Peoples R China
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Yuan, Jie,Wang, Lin-yuan,Li, Jin-mei,et al. Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2010,42(1):53-58.
APA Yuan, Jie.,Wang, Lin-yuan.,Li, Jin-mei.,Cao, Ning-jia.,Wang, Liang.,...&Wang, Xue-feng.(2010).Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy.JOURNAL OF MOLECULAR NEUROSCIENCE,42(1),53-58.
MLA Yuan, Jie,et al."Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy".JOURNAL OF MOLECULAR NEUROSCIENCE 42.1(2010):53-58.
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