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学科主题: 公共卫生
题名:
Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy
作者: Yuan, Jie1; Wang, Lin-yuan2; Li, Jin-mei1; Cao, Ning-jia4; Wang, Liang1; Feng, Gui-bo1; Xue, Tao3; Lu, Yang1; Wang, Xue-feng1
关键词: Temporal lobe epilepsy ; RhoA ; Axon growth ; Neuronal loss
刊名: JOURNAL OF MOLECULAR NEUROSCIENCE
发表日期: 2010-09-01
DOI: 10.1007/s12031-010-9330-4
卷: 42, 期:1, 页:53-58
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: GTPASES ; BRAIN ; PATHWAY ; REGENERATION ; INHIBITION ; SEIZURES ; Y-27632 ; CNS
英文摘要:

The small guanosine triphosphatase RhoA has recently been implicated in the pathogenesis of epilepsy in animals. In this study, we investigated the expression of RhoA in human epilepsy. Brain tissue samples from 40 patients with intractable epilepsy and 14 histologically normal temporal lobes from control patients were used to compare RhoA immunoreactivity using immunohistochemistry, immunofluorescent staining, and western blotting. Immunohistochemical staining and western blot analysis showed that RhoA immunoreactivity was increased in the patient group (p<0.05). Immunofluorescent staining showed that RhoA was mainly expressed on cell membranes and in the cytoplasm. Our findings demonstrate that upregulation of RhoA immunoreactivity occurs in the brains of patients with intractable epilepsy.

语种: 英语
项目资助者: local ethics committee ; National Board of the Medical Affairs
WOS记录号: WOS:000280571900007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53381
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing Key Lab Neurol, Chongqing 400016, Peoples R China
2.Peking Univ, Sch Publ Hlth, Beijing 100083, Peoples R China
3.Chongqing Med Univ, Affiliated Hosp 2, Dept Neurol, Chongqing 400010, Peoples R China
4.Shaanxi Prov Peoples Hosp, Xian 710068, Peoples R China

Recommended Citation:
Yuan, Jie,Wang, Lin-yuan,Li, Jin-mei,et al. Altered Expression of the Small Guanosine Triphosphatase RhoA in Human Temporal Lobe Epilepsy[J]. JOURNAL OF MOLECULAR NEUROSCIENCE,2010,42(1):53-58.
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