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学科主题: 临床医学
题名:
Complement Factor I Polymorphism Is Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Population
作者: Yang, Fei1,3,4; Sun, Yaoyao1,3,4; Jin, Zhongtian2; Cheng, Yong1,3,4; Li, Shanshan1,3,4; Bai, Yujing1,3,4; Huang, Lvzhen1,3,4; Li, Xiaxin1,3,4
关键词: Complement factor I ; Polymorphism ; Neovascular age-related macular degeneration ; Polypoidal choroidal vasculopathy ; Chinese population
刊名: OPHTHALMOLOGICA
发表日期: 2014
DOI: 10.1159/000358241
卷: 232, 期:1, 页:37-45
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Ophthalmology
研究领域[WOS]: Ophthalmology
关键词[WOS]: SUSCEPTIBILITY GENES ; ALTERNATIVE PATHWAY ; ACTIVATION ; VARIANTS ; RISK ; MACULOPATHY ; PROGRESSION ; SYSTEM
英文摘要:

Purpose: To identify the associations of the two complement factor I (CFI) polymorphisms rs10033900 and rs2285714 with risk of neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a Chinese case-control study. Methods: A total of 900 subjects-300 controls, 300 cases with nAMD and 300 cases with PCV were included in the present study. Genomic DNA was extracted from venous blood leukocytes. The allelic variants of rs10033900 and rs2285714 were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The differences in allele distribution between the cases and controls were tested by a X-2 test with age and gender adjusted for by logistic regression analysis. We also performed a meta-analysis of the case-control studies of rs10033900 and rs2285714 based on the currently available evidence from the literature. The meta-analysis was conducted via an inverse-variance, fixed-effects model, as previously described. Results: No statistically significant association was observed between the two polymorphisms of CFI and AMD risk, including nAMD, PCV and combined AMD (p > 0.05 for all comparisons). By meta-analysis, we detected significant associations between both of the SNPs and late AMD, which is consistent with previous results (odds ratio, OR, rs10033900 = 0.814, p rs10033900 < 0.001; OR rs2285714 = 1.221, p rs2285714 < 0.001). For rs2285714, the results of the meta-analysis were less reliable due to its heterogeneity. Conclusions: In our case-control study, neither of the two SNPs most studied (rs10033900 or rs2285714) in the CFI gene was a risk factor for developing nAMD or PCV in a Chinese population. Additional large, comprehensive and well-designed association studies are needed to better understand the role of ethnicity and other gene interactions in the association between the CFI gene and AMD. (C) 2014 S. Karger AG, Basel

语种: 英语
所属项目编号: 2011CB510200 ; 81100666 ; Z121100005312006
项目资助者: National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Research Fund for Science and Technology Program of Beijing
WOS记录号: WOS:000338000200004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53382
Appears in Collections:北京大学第二临床医学院_眼科_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
4.Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing, Peoples R China

Recommended Citation:
Yang, Fei,Sun, Yaoyao,Jin, Zhongtian,et al. Complement Factor I Polymorphism Is Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Population[J]. OPHTHALMOLOGICA,2014,232(1):37-45.
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