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IR@PKUHSC  > 北京大学第二临床医学院  > 肿瘤科  > 期刊论文
学科主题: 临床医学
题名:
Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese
作者: Jiang, Kewei1; Sun, Yimin2,3,4; Wang, Cheng5,6,7,8; Ji, Jiafu9; Li, Yaoping10,11; Ye, Yingjiang1; Lv, Liang1,12; Guo, Yong13; Guo, Sutang11,14; Li, Hai15; Zhang, Lianhai9; Zhou, Yanbing12; Jiang, Bo10; Ren, Yonghong2; Xu, Youchun13; Yang, Xiongfei; Liu, Hongxia4; Wang, Yirui13; Shen, Zhanlong1; Qin, Wenyan2; Guo, Peng1; Jiang, Yuyang4; Hu, Zhibin5,6,7,8; Shen, Hongbing5,6,7,8; Cheng, Jing2,3,13,17; Yang, Yinxue15,18; Wang, Shan1
关键词: GWAS ; colorectal cancer ; association
刊名: ONCOTARGET
发表日期: 2015-11-24
卷: 6, 期:37, 页:40327-40336
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: SENSING ION CHANNELS ; RISK ; POPULATION ; METAANALYSIS ; INFLAMMATION ; HINT1 ; SCAN ; SUPPRESSOR ; EXPRESSION ; VARIANT
英文摘要:

Genome-wide association studies (GWAS) have reported a number of loci harboring common variants that influence risk of colorectal cancer (CRC) in European descent. But all the SNPs identified explained a small fraction of total heritability. To identify more genetic factors that modify the risk of CRC, especially Chinese Han specific, we conducted a three-stage GWAS including a screening stage (932 CRC cases and 966 controls) and two independent validations (Stage 2: 1,759 CRC cases and 1,875 controls; Stage 3: 943 CRC cases and 1,838 controls). In the combined analyses, we discovered two novel loci associated with CRC: rs12522693 at 5q23.3 (CDC42SE2-CHSY3, OR = 1.31, P = 2.08 x 10(-8)) and rs17836917 at 17q12 (ASIC2-CCL2, OR = 0.75, P = 4.55 x 10(-8)). Additionally, we confirmed two previously reported risk loci, rs6983267 at 8q24.21 (OR = 1.17, P = 7.17 x 10(-7)) and rs10795668 at 10p14 (OR = 0.86, P = 2.96 x 10(-6)) in our cohorts. These results bring further insights into the CRC susceptibility and advance our understanding on etiology of CRC.

语种: 英语
所属项目编号: 2012AA020101 ; 2012CB720703 ; 31100983 ; 2012ZX09506001-010
项目资助者: China National High-Tech Research and Development Program Grant ; National Key Basic Research Program Grant ; National Natural Science Foundation of China ; Ministry of Science and Technology of China
WOS记录号: WOS:000366114400072
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53383
Appears in Collections:北京大学第二临床医学院_肿瘤科_期刊论文

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作者单位: 1.Capital Bio Corp, Hlth Sci Res Inst, Beijing 102206, Peoples R China
2.Gansu Prov Peoples Hosp, Anorectal Dept, Lanzhou 730000, Peoples R China
3.Peking Univ, Peoples Hosp, Lab Surg Oncol, Dept Gen Surg, Beijing 100044, Peoples R China
4.Natl Engn Res Ctr Beijing Biochip Technol, Beijing 102206, Peoples R China
5.Tsinghua Univ, Grad Sch Shenzhen, State Key Lab Breeding Base, Shenzhen Key Lab Chem Biol, Shenzhen 518055, Peoples R China
6.Nanjing Med Univ, Clin Epidemiol Sect, Jiangsu Key Lab Canc Biomarkers Prevent & Treatme, Ctr Canc, Nanjing 211166, Jiangsu, Peoples R China
7.Nanjing Med Univ, Dept Epidemiol & Biostat, Nanjing 211166, Jiangsu, Peoples R China
8.Nanjing Med Univ, Minist Educ MOE, Key Lab Modern Toxicol, Sch Publ Hlth, Nanjing 211166, Jiangsu, Peoples R China
9.Nanjing Med Univ, State Key Lab Reprod Med, Nanjing 210029, Jiangsu, Peoples R China
10.Peking Univ, Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res, Dept Surg,Minist Educ, Beijing 100142, Peoples R China
11.Shanxi Med Univ, Affiliated Canc Hosp, Shanxi Canc Hosp & Inst, Dept Colorectal Surg, Taiyuan 030001, Peoples R China
12.Natl Engn Res Ctr Beijing Biochip Technol, Shanxi Branch Ctr, Taiyuan, Peoples R China
13.Qingdao Univ, Coll Med, Affiliated Hosp, Dept Gen Surg, Qingdao 266003, Peoples R China
14.Tsinghua Univ, Sch Med, Med Syst Biol Res Ctr, Dept Biomed Engn, Beijing 100084, Peoples R China
15.Shanxi Med Univ, Affiliated Canc Hosp, Shanxi Canc Hosp & Inst, Dept Mol Biol, Taiyuan 030001, Peoples R China
16.Ningxia Med Univ, Gen Hosp, Dept Anal Colorectal Surg, Yinchuan 750004, Peoples R China
17.Tsinghua Univ, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
18.Natl Engn Res Ctr Beijing Biochip Technol, Ningxia Branch Ctr, Yinchuan 750004, Peoples R China

Recommended Citation:
Jiang, Kewei,Sun, Yimin,Wang, Cheng,et al. Genome-wide association study identifies two new susceptibility loci for colorectal cancer at 5q23.3 and 17q12 in Han Chinese[J]. ONCOTARGET,2015,6(37):40327-40336.
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