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学科主题临床医学
Complement Factor I Polymorphism Is Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Population
Yang, Fei1,3,4; Sun, Yaoyao1,3,4; Jin, Zhongtian2; Cheng, Yong1,3,4; Li, Shanshan1,3,4; Bai, Yujing1,3,4; Huang, Lvzhen1,3,4; Li, Xiaxin1,3,4
关键词Complement Factor i Polymorphism Neovascular Age-related Macular Degeneration Polypoidal Choroidal Vasculopathy Chinese Population
刊名OPHTHALMOLOGICA
2014
DOI10.1159/000358241
232期:1页:37-45
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology
研究领域[WOS]Ophthalmology
关键词[WOS]SUSCEPTIBILITY GENES ; ALTERNATIVE PATHWAY ; ACTIVATION ; VARIANTS ; RISK ; MACULOPATHY ; PROGRESSION ; SYSTEM
英文摘要

Purpose: To identify the associations of the two complement factor I (CFI) polymorphisms rs10033900 and rs2285714 with risk of neovascular age-related macular degeneration (nAMD) and polypoidal choroidal vasculopathy (PCV) in a Chinese case-control study. Methods: A total of 900 subjects-300 controls, 300 cases with nAMD and 300 cases with PCV were included in the present study. Genomic DNA was extracted from venous blood leukocytes. The allelic variants of rs10033900 and rs2285714 were determined by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry. The differences in allele distribution between the cases and controls were tested by a X-2 test with age and gender adjusted for by logistic regression analysis. We also performed a meta-analysis of the case-control studies of rs10033900 and rs2285714 based on the currently available evidence from the literature. The meta-analysis was conducted via an inverse-variance, fixed-effects model, as previously described. Results: No statistically significant association was observed between the two polymorphisms of CFI and AMD risk, including nAMD, PCV and combined AMD (p > 0.05 for all comparisons). By meta-analysis, we detected significant associations between both of the SNPs and late AMD, which is consistent with previous results (odds ratio, OR, rs10033900 = 0.814, p rs10033900 < 0.001; OR rs2285714 = 1.221, p rs2285714 < 0.001). For rs2285714, the results of the meta-analysis were less reliable due to its heterogeneity. Conclusions: In our case-control study, neither of the two SNPs most studied (rs10033900 or rs2285714) in the CFI gene was a risk factor for developing nAMD or PCV in a Chinese population. Additional large, comprehensive and well-designed association studies are needed to better understand the role of ethnicity and other gene interactions in the association between the CFI gene and AMD. (C) 2014 S. Karger AG, Basel

语种英语
WOS记录号WOS:000338000200004
项目编号2011CB510200 ; 81100666 ; Z121100005312006
资助机构National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; Research Fund for Science and Technology Program of Beijing
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53386
专题北京大学第二临床医学院_病理科
北京大学第二临床医学院_眼科
北京大学第二临床医学院_检验科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Peking Univ, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
3.Minist Educ, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
4.Beijing Key Lab Diag & Therapy Retinal & Choroid, Beijing, Peoples R China
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GB/T 7714
Yang, Fei,Sun, Yaoyao,Jin, Zhongtian,et al. Complement Factor I Polymorphism Is Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Population[J]. OPHTHALMOLOGICA,2014,232(1):37-45.
APA Yang, Fei.,Sun, Yaoyao.,Jin, Zhongtian.,Cheng, Yong.,Li, Shanshan.,...&Li, Xiaxin.(2014).Complement Factor I Polymorphism Is Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Population.OPHTHALMOLOGICA,232(1),37-45.
MLA Yang, Fei,et al."Complement Factor I Polymorphism Is Not Associated with Neovascular Age-Related Macular Degeneration and Polypoidal Choroidal Vasculopathy in a Chinese Population".OPHTHALMOLOGICA 232.1(2014):37-45.
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