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学科主题基础医学
ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells
Peng, SY; Wang, WP; Meng, J; Li, T; Zhang, H; Li, YM; Chen, P; Ma, KT; Zhou, CY
关键词Isl1 Beta2 Interaction Insulin Gene Transcription
刊名BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION
2005-12-20
DOI10.1016/j.bbaexp.2005.08.013
1731期:3页:154-159
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]PROTEIN ; HOMEODOMAIN ; DOMAIN ; EXPRESSION ; PANCREAS ; ELEMENTS ; LIVER ; PDX-1
英文摘要

ISL1 is a LIM homeodomain protein that plays an important role in insulin gene transcriptional activation and islet cell formation. BETA2 is a transcription factor in the basic helix-loop-helix (bHLH) family, which activates expression of tissue-specific genes in several developmental systems. In this study, we investigated the functional and physical interactions of ISL1 and BETA2 in promoting insulin gene transcription in non-beta cells. Using the luciferase assay, we demonstrated that ISL1 and BETA2 could activate insulin gene transcription synergistically. Co-immunoprecipitation also supported that ISL1 and BETA2 appear in one complex and this physical interaction mediates the synergy between these two proteins. (c) 2005 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000233861000003
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被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53389
专题北京大学基础医学院
作者单位Peking Univ, Sch Basic Med Sci, Dept Biochem & Mol Biol, Beijing 100083, Peoples R China
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Peng, SY,Wang, WP,Meng, J,et al. ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells[J]. BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION,2005,1731(3):154-159.
APA Peng, SY.,Wang, WP.,Meng, J.,Li, T.,Zhang, H.,...&Zhou, CY.(2005).ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells.BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION,1731(3),154-159.
MLA Peng, SY,et al."ISL1 physically interacts with BETA2 to promote insulin gene transcriptional synergy in non-beta cells".BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION 1731.3(2005):154-159.
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