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Investigation of copy-number variations of C8orf4 in hematological malignancies
Zhang, Jiahao2; Gao, Yan3; Zhao, Xiaosu4; Guan, Ming5; Zhang, Wei1,6; Wan, Jun1,6,7; Yu, Bo1
关键词Cnv C8orf4 Hematological Malignancies
刊名MEDICAL ONCOLOGY
2011-12-01
DOI10.1007/s12032-010-9698-6
suppl.1页:S647-S652
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; STRUCTURAL VARIATION ; GENE-EXPRESSION ; TC1 C8ORF4 ; THYROID-CANCER ; TC-1 ; DELETION ; HETEROZYGOSITY
英文摘要

C8orf4, thyroid cancer-1 (TC1), was first identified in papillary thyroid carcinoma and encodes a nucleus-localized protein. A recent array-based study implicated the presence of copy-number variations (CNVs) of C8orf4 in the genomes of acute myelogenous leukemia. However, the functional impact of such regions needs to be extensively investigated in large amount of clinical samples. The purpose of this study is to confirm the relationship between C8orf4 CNVs and hematological malignancies. In our study, we collected bone marrow samples from 515 hematological malignancies and 102 healthy controls. And the CNVs of C8orf4 were detected by real-time PCR. We found significant association between the copy-number deletions of C8orf4 and the risk of these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). We also found that the expression of C8orf4 mRNA was relatively lower in the samples with 1 copy of DNA than those with 2 copies of DNA. The CNVs of C8orf4 were associated with the risk of hematological malignancies.

语种英语
WOS记录号WOS:000301047200097
项目编号5102008 ; KM201010025003
资助机构Beijing Natural Science Foundation
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53390
专题北京大学第二临床医学院_血液科
作者单位1.Capital Med Univ, Dept Anat, Beijing, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med, Shenzhen 518036, Guangdong, Peoples R China
3.Fudan Univ, Worldwide Med Ctr, Huashan Hosp, Shanghai Med Coll, Shanghai 200433, Peoples R China
4.Peking Univ, Dept Hematol, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
5.Fudan Univ, Dept Lab Med, Cent Lab, Huashan Hosp, Shanghai 200433, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
7.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jiahao,Gao, Yan,Zhao, Xiaosu,et al. Investigation of copy-number variations of C8orf4 in hematological malignancies[J]. MEDICAL ONCOLOGY,2011,suppl.1:S647-S652.
APA Zhang, Jiahao.,Gao, Yan.,Zhao, Xiaosu.,Guan, Ming.,Zhang, Wei.,...&Yu, Bo.(2011).Investigation of copy-number variations of C8orf4 in hematological malignancies.MEDICAL ONCOLOGY,suppl.1,S647-S652.
MLA Zhang, Jiahao,et al."Investigation of copy-number variations of C8orf4 in hematological malignancies".MEDICAL ONCOLOGY suppl.1(2011):S647-S652.
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