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学科主题: 临床医学
题名:
Investigation of copy-number variations of C8orf4 in hematological malignancies
作者: Zhang, Jiahao2; Gao, Yan3; Zhao, Xiaosu4; Guan, Ming5; Zhang, Wei1,6; Wan, Jun1,6,7; Yu, Bo1
关键词: CNV ; C8orf4 ; Hematological malignancies
刊名: MEDICAL ONCOLOGY
发表日期: 2011-12-01
DOI: 10.1007/s12032-010-9698-6
卷: suppl.1, 页:S647-S652
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: ACUTE LYMPHOBLASTIC-LEUKEMIA ; CHRONIC LYMPHOCYTIC-LEUKEMIA ; HUMAN GENOME ; STRUCTURAL VARIATION ; GENE-EXPRESSION ; TC1 C8ORF4 ; THYROID-CANCER ; TC-1 ; DELETION ; HETEROZYGOSITY
英文摘要:

C8orf4, thyroid cancer-1 (TC1), was first identified in papillary thyroid carcinoma and encodes a nucleus-localized protein. A recent array-based study implicated the presence of copy-number variations (CNVs) of C8orf4 in the genomes of acute myelogenous leukemia. However, the functional impact of such regions needs to be extensively investigated in large amount of clinical samples. The purpose of this study is to confirm the relationship between C8orf4 CNVs and hematological malignancies. In our study, we collected bone marrow samples from 515 hematological malignancies and 102 healthy controls. And the CNVs of C8orf4 were detected by real-time PCR. We found significant association between the copy-number deletions of C8orf4 and the risk of these hematological malignancies including acute lymphoblastic leukemia (ALL), acute myelogenous leukemia (AML), chronic lymphocytic leukemia (CLL), chronic myelogenous leukemia (CML), multiple myeloma (MM), and myelodysplastic syndrome (MDS). We also found that the expression of C8orf4 mRNA was relatively lower in the samples with 1 copy of DNA than those with 2 copies of DNA. The CNVs of C8orf4 were associated with the risk of hematological malignancies.

语种: 英语
所属项目编号: 5102008 ; KM201010025003
项目资助者: Beijing Natural Science Foundation
WOS记录号: WOS:000301047200097
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53390
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Capital Med Univ, Dept Anat, Beijing, Peoples R China
2.Shenzhen PKU HKUST Med Ctr, Shenzhen Key Lab Translat Med, Shenzhen 518036, Guangdong, Peoples R China
3.Fudan Univ, Worldwide Med Ctr, Huashan Hosp, Shanghai Med Coll, Shanghai 200433, Peoples R China
4.Peking Univ, Dept Hematol, Peoples Hosp, Inst Hematol, Beijing 100871, Peoples R China
5.Fudan Univ, Dept Lab Med, Cent Lab, Huashan Hosp, Shanghai 200433, Peoples R China
6.Hong Kong Univ Sci & Technol, Div Life Sci, Hong Kong, Hong Kong, Peoples R China
7.Shenzhen PKU HKUST Med Ctr, Biomed Res Inst, Shenzhen 518036, Guangdong, Peoples R China

Recommended Citation:
Zhang, Jiahao,Gao, Yan,Zhao, Xiaosu,et al. Investigation of copy-number variations of C8orf4 in hematological malignancies[J]. MEDICAL ONCOLOGY,2011,suppl.1:S647-S652.
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