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学科主题: 基础医学
题名:
Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells
作者: Zhang, XY; Liu, XG; Wang, W; Wang, WC; Gao, XM
刊名: IMMUNOLOGY
发表日期: 2003-04-01
卷: 108, 期:4, 页:465-473
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: MYELIN-BASIC-PROTEIN ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; RECEPTOR BETA-CHAIN ; MULTIPLE-SCLEROSIS ; PILOT TRIAL ; VACCINATION ; MECHANISMS ; THERAPY ; TOLERANCE
英文摘要:

It is known that T-cell vaccination (TCV) elicits cellular immune responses against the immunizing T cells in vivo . However, it is still unclear whether similar anti-T-cell responses are also induced in individuals responding to foreign antigen (Ag) challenge. This study was undertaken to characterize and compare anti-T-cell cellular and humoral responses of BALB/c mice after ovalbumin (OVA) immunization or TCV. Splenocytes from OVA-primed BALB/c mice proliferated in response to stimulation with a syngeneic OVA-specific T-cell clone, OVA-T3, and secreted interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). Cytotoxic T-lymphocyte (CTL) activity against the T-cell clone was also observed. Serum samples from these animals discriminated between activated and resting murine T cells, as determined by indirect immunofluorescence staining. Vaccination of BALB/c mice with OVA-T3 cells induced similar, but stronger, cellular and humoral responses. TCV-induced antibodies were not only able to distinguish between activated and resting syngeneic T cells but also positively stained allogeneic T cells from BXSB mice. Furthermore, TCV resulted in hyporesponsiveness of BALB/c mice to subsequent Ag challenge, and antisera from the immunized animals inhibited T-cell proliferation in vitro. Our data suggest that anti-T-cell antibodies, and CD4(+) and CD8(+) regulatory T lymphocytes may form a complex and co-ordinated regulatory network that plays an important role in regulating the adaptive immune responses in vivo . Implications of this observation for our understanding of the immunoregulation and peripheral tolerance are discussed.

语种: 英语
WOS记录号: WOS:000181966900006
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53392
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, XY,Liu, XG,Wang, W,et al. Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells[J]. IMMUNOLOGY,2003,108(4):465-473.
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