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学科主题基础医学
Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells
Zhang, XY; Liu, XG; Wang, W; Wang, WC; Gao, XM
刊名IMMUNOLOGY
2003-04-01
108期:4页:465-473
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]MYELIN-BASIC-PROTEIN ; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS ; RECEPTOR BETA-CHAIN ; MULTIPLE-SCLEROSIS ; PILOT TRIAL ; VACCINATION ; MECHANISMS ; THERAPY ; TOLERANCE
英文摘要

It is known that T-cell vaccination (TCV) elicits cellular immune responses against the immunizing T cells in vivo . However, it is still unclear whether similar anti-T-cell responses are also induced in individuals responding to foreign antigen (Ag) challenge. This study was undertaken to characterize and compare anti-T-cell cellular and humoral responses of BALB/c mice after ovalbumin (OVA) immunization or TCV. Splenocytes from OVA-primed BALB/c mice proliferated in response to stimulation with a syngeneic OVA-specific T-cell clone, OVA-T3, and secreted interferon-gamma (IFN-gamma) but not interleukin-4 (IL-4). Cytotoxic T-lymphocyte (CTL) activity against the T-cell clone was also observed. Serum samples from these animals discriminated between activated and resting murine T cells, as determined by indirect immunofluorescence staining. Vaccination of BALB/c mice with OVA-T3 cells induced similar, but stronger, cellular and humoral responses. TCV-induced antibodies were not only able to distinguish between activated and resting syngeneic T cells but also positively stained allogeneic T cells from BXSB mice. Furthermore, TCV resulted in hyporesponsiveness of BALB/c mice to subsequent Ag challenge, and antisera from the immunized animals inhibited T-cell proliferation in vitro. Our data suggest that anti-T-cell antibodies, and CD4(+) and CD8(+) regulatory T lymphocytes may form a complex and co-ordinated regulatory network that plays an important role in regulating the adaptive immune responses in vivo . Implications of this observation for our understanding of the immunoregulation and peripheral tolerance are discussed.

语种英语
WOS记录号WOS:000181966900006
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53392
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, XY,Liu, XG,Wang, W,et al. Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells[J]. IMMUNOLOGY,2003,108(4):465-473.
APA Zhang, XY,Liu, XG,Wang, W,Wang, WC,&Gao, XM.(2003).Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells.IMMUNOLOGY,108(4),465-473.
MLA Zhang, XY,et al."Anti-T-cell humoral and cellular responses in healthy BALB/c mice following immunization with ovalbumin or ovalbumin-specific T cells".IMMUNOLOGY 108.4(2003):465-473.
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