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学科主题口腔医学
Estrogen Aggravates Iodoacetate-induced Temporomandibular Joint Osteoarthritis
Wang, X. D.1,2; Kou, X. X.1,2; Meng, Z.3; Bi, R. Y.3; Liu, Y.1; Zhang, J. N.1; Zhou, Y. H.1,2; Gan, Y. H.3
关键词Cartilage Subchondral Bone Sexual Dimorphism Tmj Estrogen Receptor Apoptosis
刊名JOURNAL OF DENTAL RESEARCH
2013-10-01
DOI10.1177/0022034513501323
92期:10页:918-924
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
资助者National Natural Science Foundation of China ; China International Science and Technology Cooperation ; National Natural Science Foundation of China ; China International Science and Technology Cooperation
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]OVARIECTOMIZED RATS ; ARTICULAR-CARTILAGE ; CONDYLAR CARTILAGE ; SEXUAL-DIMORPHISM ; RECEPTOR-ALPHA ; CHONDROCYTES ; EXPRESSION ; DISORDERS ; APOPTOSIS ; GROWTH
英文摘要

Temporomandibular joint osteoarthritis (TMJOA) is clinically characterized by female preponderance, with a female-to-male ratio of more than 2:1; however, the underlying mechanism remains obscure. We examined the effects of estrogen on TMJOA induced by monosodium iodoacetate. Female rats were randomly and equally divided into 5 groups: control, sham-ovariectomized, and ovariectomized rats treated, respectively, with 17 beta-estradiol (E2) at doses of 0 mu g, 20 mu g, and 80 mu g/day until the end of the experiment. After induction of TMJOA, TMJs were evaluated by histopathology and microCT, and the expression of Fas, FasL, caspase 3, and caspase 8 was evaluated by real-time polymerase chain-reaction or immunohistochemistry. Another 5 groups of female rats were used to evaluate the effect of estrogen receptor antagonist ICI 182780 on E2 effects on TMJOA, when injected intraperitoneally into the control, sham-ovariectomized, and 80-mu g-E2-treated groups. We found that E2 potentiated cartilage degradation and subchondral bone erosion in iodoacetate-induced TMJOA. E2 also potentiated mRNA expression of Fas, FasL, caspase 3, and caspase 8 in the condylar cartilage. Moreover, the estrogen receptor antagonist partially blocked E2 effects on TMJOA. These findings suggest that E2 could aggravate TMJOA, which may be an important mechanism underlying the sexual dimorphism of TMJOA.

语种英语
所属项目编号81070849 ; 2010DFB32980 ; 2013DFB30306
资助者National Natural Science Foundation of China ; China International Science and Technology Cooperation ; National Natural Science Foundation of China ; China International Science and Technology Cooperation
WOS记录号WOS:000324471300011
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53393
专题北京大学口腔医学院_牙周科
作者单位1.Peking Univ Sch & Hosp Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
2.Peking Univ Sch & Hosp Stomatol, Ctr Craniofacial Stem Cell Res & Regenerat, Beijing 100081, Peoples R China
3.Peking Univ Sch & Hosp Stomatol, Ctr Temporomandibular Disorders & Orofacial Pain, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Wang, X. D.,Kou, X. X.,Meng, Z.,et al. Estrogen Aggravates Iodoacetate-induced Temporomandibular Joint Osteoarthritis[J]. JOURNAL OF DENTAL RESEARCH,2013,92(10):918-924.
APA Wang, X. D..,Kou, X. X..,Meng, Z..,Bi, R. Y..,Liu, Y..,...&Gan, Y. H..(2013).Estrogen Aggravates Iodoacetate-induced Temporomandibular Joint Osteoarthritis.JOURNAL OF DENTAL RESEARCH,92(10),918-924.
MLA Wang, X. D.,et al."Estrogen Aggravates Iodoacetate-induced Temporomandibular Joint Osteoarthritis".JOURNAL OF DENTAL RESEARCH 92.10(2013):918-924.
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