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学科主题: 临床医学
题名:
Usefulness of Plasma Copeptin as a Biomarker to Predict the Therapeutic Effectiveness of Metoprolol for Postural Tachycardia Syndrome in Children
作者: Zhao, Juan1; Du, Shuxu2; Yang, Jinyan1; Lin, Jing1; Tang, Chaoshu3,4; Du, Junbao1; Jin, Hongfang1
刊名: AMERICAN JOURNAL OF CARDIOLOGY
发表日期: 2014-08-15
DOI: 10.1016/j.amjcard.2014.05.039
卷: 114, 期:4, 页:601-605
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: ORTHOSTATIC INTOLERANCE ; MIDODRINE HYDROCHLORIDE ; ARGININE-VASOPRESSIN ; PIG PITUITARIES ; POSTERIOR LOBE ; DIAGNOSIS ; GLYCOPEPTIDE ; PRECURSOR ; EXERCISE
英文摘要:

Metoprolol is clinically used to treat postural tachycardia syndrome (POTS) in children, but its effectiveness is unsatisfactory. Biomarkers to predict therapeutic efficacy are needed. We aimed to explore changes in the plasma copeptin level for assessing the therapeutic efficacy of metoprolol for POTS in children. We included 49 children with POTS and 25 healthy children as controls. Patients received metoprolol for 1.5 to 3 months. The plasma copeptin level was measured by sandwich immunoluminometric assay. The area under the receiver operating characteristic curve was used to explore the predictive value of the plasma copeptin level. The baseline plasma copeptin level was higher in children with POTS than controls (10.524 +/- 2.016 vs 8.750 +/- 1.419 pmol/L, p <0.001) and was lower for responders than nonresponders to metoprolol (9.377 +/- 1.411 vs 12.054 +/- 1.662 pmol/L, p = 0.003). The area under the receiver operating characteristic curve was 0.889 (95% confidence interval 0.799 to 0.980). With a baseline plasma copeptin level of 10.225 pmol/L as a cutoff, the sensitivity was 90.5% and specificity 78.6% in predicting the efficacy of metoprolol in children with POTS. In conclusion, the baseline plasma copeptin level can be used as a biomarker to predict the therapeutic effectiveness of metoprolol in children with POTS. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2012BA103B03 ; 2012CB517806 ; 2011CB503904 ; 81121061
项目资助者: National Twelfth Five-Year Plan for Science &amp ; Technology Support, Beijing, PR China ; Major Basic Research Project of China, Beijing, PR China ; National Natural Science Foundation of China, Beijing, PR China
WOS记录号: WOS:000340442600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53399
Appears in Collections:北京大学第一临床医学院_儿科_期刊论文

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作者单位: 1.Peking Univ, Dept Pediat, Hosp 1, Beijing 100871, Peoples R China
2.Capital Med Univ, Shijitan Hosp, Dept Pediat, Beijing, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
4.Minist Educ, Key Lab Cardiovasc Sci, Beijing, Peoples R China

Recommended Citation:
Zhao, Juan,Du, Shuxu,Yang, Jinyan,et al. Usefulness of Plasma Copeptin as a Biomarker to Predict the Therapeutic Effectiveness of Metoprolol for Postural Tachycardia Syndrome in Children[J]. AMERICAN JOURNAL OF CARDIOLOGY,2014,114(4):601-605.
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