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学科主题: 药学
题名:
Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides
作者: Liu, JL; Zhao, M; Wang, C; Peng, SQ
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2003-11-17
DOI: 10.1016/j.bmcl.2003.08.041
卷: 13, 期:22, 页:4065-4069
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: NITRIC-OXIDE SYNTHASE ; FIBRINOGEN ; PEPTIDES
英文摘要:

1-(1′,3′-Dioxyl-4′,4′,5′,5′-tetramethyldihydroimidazol-2′-yl)-phenyl-4-yloxylacetic acid (3), and 1-(1′,3′-dioxyl-4′,4′,5′,5′-tetramethyldihydroimidazol-2′-yl)-phenyl-4-yloxylacetyl-RGDS (13), -RGDV (14), -RGDF (15) were synthesized. The ESR measurement gave the same spectroscopy for 3 and 13-15. The NO scavenging tests in vitro, anti-platelet aggregation tests in vitro and the anti-thrombosis assay in vivo indicated that introducing 3 into the N-terminal of RGDS, RGDV and RGDF the corresponding bioactivities for both of 3 and RGD peptides can be remained completely. The present combinations provided a beneficial strategy for simultaneous scavenging NO and anti-thrombosis, and for the use of spin label of RGD peptides in the conformational researches. (C) 2003 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000186486400040
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53402
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China

Recommended Citation:
Liu, JL,Zhao, M,Wang, C,et al. Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2003,13(22):4065-4069.
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