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Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides
Liu, JL; Zhao, M; Wang, C; Peng, SQ
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2003-11-17
DOI10.1016/j.bmcl.2003.08.041
13期:22页:4065-4069
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]NITRIC-OXIDE SYNTHASE ; FIBRINOGEN ; PEPTIDES
英文摘要

1-(1′,3′-Dioxyl-4′,4′,5′,5′-tetramethyldihydroimidazol-2′-yl)-phenyl-4-yloxylacetic acid (3), and 1-(1′,3′-dioxyl-4′,4′,5′,5′-tetramethyldihydroimidazol-2′-yl)-phenyl-4-yloxylacetyl-RGDS (13), -RGDV (14), -RGDF (15) were synthesized. The ESR measurement gave the same spectroscopy for 3 and 13-15. The NO scavenging tests in vitro, anti-platelet aggregation tests in vitro and the anti-thrombosis assay in vivo indicated that introducing 3 into the N-terminal of RGDS, RGDV and RGDF the corresponding bioactivities for both of 3 and RGD peptides can be remained completely. The present combinations provided a beneficial strategy for simultaneous scavenging NO and anti-thrombosis, and for the use of spin label of RGD peptides in the conformational researches. (C) 2003 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000186486400040
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53402
专题北京大学药学院
作者单位Peking Univ, Coll Pharmaceut Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, JL,Zhao, M,Wang, C,et al. Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2003,13(22):4065-4069.
APA Liu, JL,Zhao, M,Wang, C,&Peng, SQ.(2003).Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,13(22),4065-4069.
MLA Liu, JL,et al."Synthesis and bioactivities of nitronyl nitroxide and RGD containing pseudopeptides".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 13.22(2003):4065-4069.
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