学科主题临床医学
Association of MicroRNA-181c Expression with the Progression and Prognosis of Human Gastric Carcinoma
Cui, Meihua1; Yue, Lin1; Fu, Yi1; Yu, Weidong3; Hou, Xiaolin1; Zhang, Xiuru2
关键词Microrna-181c Gastric Cancer Real-time Pcr Prognosis
刊名HEPATO-GASTROENTEROLOGY
2013-07-01
DOI10.5754/hge121333
60期:125页:961-964
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Surgery
研究领域[WOS]Gastroenterology & Hepatology ; Surgery
关键词[WOS]GLIOBLASTOMA PATIENTS ; TARGETING BCL2 ; CANCER
英文摘要

Background/Aims: The relationship of miR-181c, a potential tumor regulatory factor with gastric cancer is not well studied. We have investigated this relationship in our study. Methodology: Paraffin-embedded tissue specimens from 103 gastric cancer patients were subjected to total RNA extraction. Reverse transcription real-time fluorescence quantitative PCR was used to detect miR-181c expression. Its relative expression was correlated with the patients′ clinicopathological features. Also, the 5-year survival rate and median survival time were correlated with the miR-181c expression level. Results: miR-181c expression was significantly and directly correlated with the degree of tumor differentiation, invasive depth and clinical stage. Moreover, lymph node metastasis was significantly related with higher miR-181c expression. However, miR-181c expression was no significantly correlated with gender, age, tumor location and distant metastasis. The 5-year overall survival rate and median-survival time were significantly greater in patients with low expression of miR-181c. Conclusions: miR-181c expression level was significantly related to several clinicopathological features of gastric cancer; therefore, miR-181c probably plays a role in its development and progression. This relationship needs to be studied in detail, so that the potential use of miR-181c as a marker for gastric cancer and therapeutic target can be explored.

语种英语
WOS记录号WOS:000330327700002
项目编号2009-3174 ; 200904
资助机构Capital Medical Development Research Foundation ; Aerospace Center Hospital Foundation
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53404
专题北京大学第二临床医学院_临床分子生物学研究所
作者单位1.Aerosp Ctr Hosp, Dept Pathol, Beijing 100049, Peoples R China
2.Aerosp Ctr Hosp, Dept Gastroenterol, Beijing 100049, Peoples R China
3.Peking Univ, Peoples Hosp, Inst Clin Mol Biol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Cui, Meihua,Yue, Lin,Fu, Yi,et al. Association of MicroRNA-181c Expression with the Progression and Prognosis of Human Gastric Carcinoma[J]. HEPATO-GASTROENTEROLOGY,2013,60(125):961-964.
APA Cui, Meihua,Yue, Lin,Fu, Yi,Yu, Weidong,Hou, Xiaolin,&Zhang, Xiuru.(2013).Association of MicroRNA-181c Expression with the Progression and Prognosis of Human Gastric Carcinoma.HEPATO-GASTROENTEROLOGY,60(125),961-964.
MLA Cui, Meihua,et al."Association of MicroRNA-181c Expression with the Progression and Prognosis of Human Gastric Carcinoma".HEPATO-GASTROENTEROLOGY 60.125(2013):961-964.
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