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学科主题临床医学
Association of natural killer cells in allografts with transplant outcomes in patients receiving G-CSF-mobilized PBSC grafts and G-CSF-primed BM grafts from HLA-haploidentical donors
Zhao, X. -Y; Chang, Y. -J; Xu, L. -P; Liu, D. -H; Liu, K. -Y; Huang, X. -J
关键词Hla-mismatched Haploidentical Hsct Gvhd Cd56(Bright) Nk Cells
刊名BONE MARROW TRANSPLANTATION
2009-12-01
DOI10.1038/bmt.2009.73
44期:11页:721-728
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW TRANSPLANTS ; MATCHED SIBLING DONORS ; VERSUS-HOST-DISEASE ; PERIPHERAL-BLOOD ; MISMATCHED/HAPLOIDENTICAL BLOOD ; HEMATOLOGICAL MALIGNANCIES ; RECEPTOR EXPRESSION ; CLINICAL-OUTCOMES ; T-CELLS ; IMPACT
英文摘要

The aim of this study was to investigate the effects of natural killer (NK) cells on transplant outcomes in patients receiving G-CSF-mobilized PBSC grafts and G-CSF-primed BM grafts from HLA-haploidentical donors. Forty-one haploidentical allogeneic hematopoietic SCT patients were analyzed according to the NK cell concentration in relation to acute GVHD (aGVHD), chronic GVHD (cGVHD), TRM and leukemia-free survival. The patients receiving a higher dose of CD56(bright) NK cells (> 1.9 x 10(6)/kg) showed a higher incidence of grades II-IV aGVHD (hazard risk (HR), 2.872; P = 0.022) and cGVHD (HR, 2.884; P = 0.039). A higher CD56(dim)/CD56(bri) NK cell ratio (> 8.0) was correlated with a decreased risk of III-IV aGVHD (HR, 0.290; P = 0.065) and TRM (HR, 0.072; P = 0.012), thereby increasing the rate of leukemia-free survival (HR, 0.174; P = 0.007) after haploidentical transplantation without in vitro T-cell depletion. Our results suggest that a high allograft CD56(dim)/CD56(bright) NK cell ratio (> 8.0) plays an important role in improving transplant outcomes. A higher dose of CD56(bright) NK cells might be a predictor for a higher incidence of GVHD. Bone Marrow Transplantation (2009) 44, 721-728; doi: 10.1038/bmt.2009.73; published online 20 April 2009

语种英语
WOS记录号WOS:000272557200003
项目编号30800485 ; 30725038 ; 2006AA02Z4A0 ; IRT0702 ; 2008605
资助机构National Natural Science Foundation of China ; National Outstanding Young Scientist&prime ; s Foundation of China ; Hi-Tech Research and Development Program of China ; Program for Innovative Research Team in University ; Beijing Nova program
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53405
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Dept Hematopoiet Stem Cell Transplantat, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Zhao, X. -Y,Chang, Y. -J,Xu, L. -P,et al. Association of natural killer cells in allografts with transplant outcomes in patients receiving G-CSF-mobilized PBSC grafts and G-CSF-primed BM grafts from HLA-haploidentical donors[J]. BONE MARROW TRANSPLANTATION,2009,44(11):721-728.
APA Zhao, X. -Y,Chang, Y. -J,Xu, L. -P,Liu, D. -H,Liu, K. -Y,&Huang, X. -J.(2009).Association of natural killer cells in allografts with transplant outcomes in patients receiving G-CSF-mobilized PBSC grafts and G-CSF-primed BM grafts from HLA-haploidentical donors.BONE MARROW TRANSPLANTATION,44(11),721-728.
MLA Zhao, X. -Y,et al."Association of natural killer cells in allografts with transplant outcomes in patients receiving G-CSF-mobilized PBSC grafts and G-CSF-primed BM grafts from HLA-haploidentical donors".BONE MARROW TRANSPLANTATION 44.11(2009):721-728.
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