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学科主题临床医学
BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer
Chen, Yanglin2; Zhou, Jing2; Xu, Ye1; Li, Zhaosheng1; Wen, Xianzi2; Yao, Lihua1; Xie, Yuntao1; Deng, Dajun2
刊名CANCER SCIENCE
2009-09-01
DOI10.1111/j.1349-7006.2009.01225.x
100期:9页:1663-1667
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]TUMOR-SUPPRESSOR GENES ; HYPERMETHYLATION ; REPAIR ; WOMEN
英文摘要

Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation specific PCR in 536 sporadic breast cancers. Survival curves for patients with methylated and unmethylated BRCA1 were compared using the log-rank tests. Twenty-six percent (139/536) of patients exhibited BRCA1 methylation in their tumors. The degree of BRCA1 methylation was correlated with clinical stages of breast cancer, but was not significant. Patients with BRCA1 methylated tumors had a significantly worse 5-year disease-free survival (DFS) and 5-year disease-specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2% vs 82.6%, P = 0.045; DSS 80.5% vs 87%, P = 0.038, two-sided). In conclusions, BRCA1 methylation is a frequent event in breast cancer and is associated with poor clinical outcome in Chinese women with breast cancer. (Cancer Sci 2009; 100: 1663-1667).

语种英语
WOS记录号WOS:000268923800015
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53413
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_病因学研究室
北京大学临床肿瘤学院_乳腺中心实验室
北京大学临床肿瘤学院_教育处
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Breast Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Etiol Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Yanglin,Zhou, Jing,Xu, Ye,et al. BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer[J]. CANCER SCIENCE,2009,100(9):1663-1667.
APA Chen, Yanglin.,Zhou, Jing.,Xu, Ye.,Li, Zhaosheng.,Wen, Xianzi.,...&Deng, Dajun.(2009).BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer.CANCER SCIENCE,100(9),1663-1667.
MLA Chen, Yanglin,et al."BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer".CANCER SCIENCE 100.9(2009):1663-1667.
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