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学科主题: 临床医学
题名:
BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer
作者: Chen, Yanglin2; Zhou, Jing2; Xu, Ye1; Li, Zhaosheng1; Wen, Xianzi2; Yao, Lihua1; Xie, Yuntao1; Deng, Dajun2
刊名: CANCER SCIENCE
发表日期: 2009-09-01
DOI: 10.1111/j.1349-7006.2009.01225.x
卷: 100, 期:9, 页:1663-1667
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: TUMOR-SUPPRESSOR GENES ; HYPERMETHYLATION ; REPAIR ; WOMEN
英文摘要:

Transcriptional inactivation of breast cancer gene 1 (BRCA1) by DNA methylation is a frequent event in sporadic breast cancers. To investigate whether BRCA1 methylation is associated with survival in Chinese patients with sporadic breast cancer, BRCA1 methylation was determined using methylation specific PCR in 536 sporadic breast cancers. Survival curves for patients with methylated and unmethylated BRCA1 were compared using the log-rank tests. Twenty-six percent (139/536) of patients exhibited BRCA1 methylation in their tumors. The degree of BRCA1 methylation was correlated with clinical stages of breast cancer, but was not significant. Patients with BRCA1 methylated tumors had a significantly worse 5-year disease-free survival (DFS) and 5-year disease-specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2% vs 82.6%, P = 0.045; DSS 80.5% vs 87%, P = 0.038, two-sided). In conclusions, BRCA1 methylation is a frequent event in breast cancer and is associated with poor clinical outcome in Chinese women with breast cancer. (Cancer Sci 2009; 100: 1663-1667).

语种: 英语
所属项目编号: 2005CB522403
项目资助者: National Basic Research Program of China
WOS记录号: WOS:000268923800015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53413
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Breast Ctr, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China
2.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst,Etiol Lab, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Yanglin,Zhou, Jing,Xu, Ye,et al. BRCA1 promoter methylation associated with poor survival in Chinese patients with sporadic breast cancer[J]. CANCER SCIENCE,2009,100(9):1663-1667.
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