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IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科  > 期刊论文
学科主题: 临床医学
题名:
Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide
作者: Li, Xiao-Da1; Liang, Xiao-Long2; Yue, Xiu-Li1; Wang, Jin-Rui3; Li, Chang-Hui2; Deng, Zi-Jian2; Jing, Li-Jia1; Lin, Li1; Qu, En-Ze3; Wang, Shu-Min3; Wu, Chun-Long4; Wu, Hua-Xing4; Dai, Zhi-Fei2
刊名: JOURNAL OF MATERIALS CHEMISTRY B
发表日期: 2014
DOI: 10.1039/c3tb21281e
卷: 2, 期:2, 页:217-223
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Materials Science, Biomaterials
研究领域[WOS]: Materials Science
关键词[WOS]: BLUE NANOPARTICLES OPERATE ; DRUG-DELIVERY ; NANO-GRAPHENE ; POLYPYRROLE NANOPARTICLES ; GOLD NANOPARTICLES ; CONTRAST AGENT ; COPPER SULFIDE ; CANCER-THERAPY ; ULTRASOUND ; MICROBUBBLES
英文摘要:

A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

语种: 英语
所属项目编号: 81225011 ; 81371580 ; 21273014 ; 81230036
项目资助者: National Natural Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China
WOS记录号: WOS:000327849200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53423
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Harbin Inst Technol, Sch Life Sci & Technol, Nanomed & Biosensor Lab, Harbin 150080, Peoples R China
2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 3, Harbin 150080, Peoples R China

Recommended Citation:
Li, Xiao-Da,Liang, Xiao-Long,Yue, Xiu-Li,et al. Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(2):217-223.
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