IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科
学科主题临床医学
Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide
Li, Xiao-Da1; Liang, Xiao-Long2; Yue, Xiu-Li1; Wang, Jin-Rui3; Li, Chang-Hui2; Deng, Zi-Jian2; Jing, Li-Jia1; Lin, Li1; Qu, En-Ze3; Wang, Shu-Min3; Wu, Chun-Long4; Wu, Hua-Xing4; Dai, Zhi-Fei2
刊名JOURNAL OF MATERIALS CHEMISTRY B
2014
DOI10.1039/c3tb21281e
2期:2页:217-223
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Biomaterials
资助者National Natural Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China ; National Natural Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China
研究领域[WOS]Materials Science
关键词[WOS]BLUE NANOPARTICLES OPERATE ; DRUG-DELIVERY ; NANO-GRAPHENE ; POLYPYRROLE NANOPARTICLES ; GOLD NANOPARTICLES ; CONTRAST AGENT ; COPPER SULFIDE ; CANCER-THERAPY ; ULTRASOUND ; MICROBUBBLES
英文摘要

A novel multifunctional theranostic agent has been successfully fabricated by loading iron oxide nanoparticles into poly(lactic acid) (PLA) microcapsules followed by surface functionalization with graphene oxide. Both in vitro and in vivo experiments proved that the resulting microcapsules could serve as contrast agents to simultaneously enhance ultrasound, magnetic resonance and photoacoustic imaging. The composite microcapsules show good biocompatibility and rapid response to magnetic fields. Due to the strong absorption of the near-infrared light, the composite microcapsules could efficiently kill cancer cells upon NIR laser irradiation. In addition, it was found that such a photothermal effect could be obviously enhanced by applying an external magnetic field. In a nutshell, this multifunctional microcapsule can be developed as a promising platform that integrates multimodality imaging and therapy capabilities for effective cancer theranostics.

语种英语
所属项目编号81225011 ; 81371580 ; 21273014 ; 81230036
资助者National Natural Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China ; National Natural Science Foundation for Distinguished Young Scholars ; National Natural Science Foundation of China ; State Key Program of National Natural Science of China
WOS记录号WOS:000327849200008
引用统计
被引频次:36[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53423
专题北京大学第三临床医学院_超声诊断科
作者单位1.Harbin Inst Technol, Sch Life Sci & Technol, Nanomed & Biosensor Lab, Harbin 150080, Peoples R China
2.Peking Univ, Coll Engn, Dept Biomed Engn, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
4.Harbin Med Univ, Affiliated Hosp 3, Harbin 150080, Peoples R China
推荐引用方式
GB/T 7714
Li, Xiao-Da,Liang, Xiao-Long,Yue, Xiu-Li,et al. Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide[J]. JOURNAL OF MATERIALS CHEMISTRY B,2014,2(2):217-223.
APA Li, Xiao-Da.,Liang, Xiao-Long.,Yue, Xiu-Li.,Wang, Jin-Rui.,Li, Chang-Hui.,...&Dai, Zhi-Fei.(2014).Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide.JOURNAL OF MATERIALS CHEMISTRY B,2(2),217-223.
MLA Li, Xiao-Da,et al."Imaging guided photothermal therapy using iron oxide loaded poly(lactic acid) microcapsules coated with graphene oxide".JOURNAL OF MATERIALS CHEMISTRY B 2.2(2014):217-223.
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