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学科主题基础医学
Association of interleukin-12 p40 gene 3 ′-untranslated region polymorphism and outcome of HCV infection
Yin, Li-Min1; Zhu, Wan-Fu1; Wei, Lai3; Xu, Xiao-Yuan2; Sun, De-Gui4; Wang, Yan-Bin5; Fan, Wen-Mei1; Yu, Min2; Tian, Xiu-Lan2; Wang, Qi-Xin3; Gao, Yan3; Zhuang, Hui1
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-08-15
10期:16页:2330-2333
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]HEPATITIS-C VIRUS ; RECOMBINANT HUMAN INTERLEUKIN-12 ; IMMUNE-RESPONSES ; INNATE RESISTANCE ; ADAPTIVE IMMUNITY ; NATURAL-HISTORY ; IL-12 ; SUSCEPTIBILITY ; PERSISTENCE ; THERAPY
英文摘要

AIM: To investigate the effect of interleukin-12 p40 gene (IL12B) 3′-untranslated region polymorphism on the outcome of HCV infection.

METHODS: A total of 133 patients who had been infected with HCV for 12-25 (18.2 +/- 3.8) years, were enrolled in this study. Liver biochemical tests were performed with an automated analyzer and HCV RNA was detected by fluorogenic quantitative polymerase chain reaction. B-mode ultrasound was used for liver examination. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used for the detection of IL12B (1188A/C) polymorphism.

RESULTS: Self-limited infection was associated with AC genotype (OR = 3.48; P = 0.001) and persistent infection was associated with AA genotype (OR = 0.34; P = 0.014) at site 1188 of IL12B. In patients with persistent HCV infection, no significant differences were found regarding the age, gender, duration of infection and biochemical characteristics (P>0.05). According to B-mode ultrasound imaging and clinical diagnosis, patients with persistent infection were divided into groups based on the severity of infection. No significant differences were found in the frequency of IL-12 genotype (1188A/C) between different groups (P>0.05).

CONCLUSION: The polymorphism of IL12B (1188A/C) appears to have some influence on the outcome of HCV infection.

语种英语
WOS记录号WOS:000208317600005
项目编号2001BA705B06
资助机构National Key Technologies Research and Development Program of China
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53426
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
北京大学第一临床医学院_感染疾病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Peking Univ, Dept Microbiol, Sch Basic Med Sci, Beijing 100083, Peoples R China
2.Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China
3.Peking Univ, Inst Hepatol, Peoples Hosp, Beijing 100044, Peoples R China
4.Guan Stn Dis Prevent & Control, Guan 102700, Hebei Province, Peoples R China
5.Beijing Ditan Hosp, Beijing 100730, Peoples R China
推荐引用方式
GB/T 7714
Yin, Li-Min,Zhu, Wan-Fu,Wei, Lai,等. Association of interleukin-12 p40 gene 3 ′-untranslated region polymorphism and outcome of HCV infection[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(16):2330-2333.
APA Yin, Li-Min.,Zhu, Wan-Fu.,Wei, Lai.,Xu, Xiao-Yuan.,Sun, De-Gui.,...&Zhuang, Hui.(2004).Association of interleukin-12 p40 gene 3 ′-untranslated region polymorphism and outcome of HCV infection.WORLD JOURNAL OF GASTROENTEROLOGY,10(16),2330-2333.
MLA Yin, Li-Min,et al."Association of interleukin-12 p40 gene 3 ′-untranslated region polymorphism and outcome of HCV infection".WORLD JOURNAL OF GASTROENTEROLOGY 10.16(2004):2330-2333.
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