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学科主题: 临床医学
题名:
Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis
作者: Sun, Qingli; Xie, Ruping; Fu, Yu; Li, Xiaogang; Fan, Dongsheng
关键词: estrogen receptor ; gene ; polymorphism ; multiple sclerosis ; case-control study
刊名: NEURAL REGENERATION RESEARCH
发表日期: 2011-07-01
DOI: 10.3969/j.issn.1673-5374.2011.19.009
卷: 6, 期:19, 页:1488-1492
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Neurosciences
研究领域[WOS]: Cell Biology ; Neurosciences & Neurology
关键词[WOS]: EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; DEMYELINATING DISEASE ; JAPANESE PATIENTS ; HUMAN-BREAST ; ALPHA ; ASSOCIATION ; EXPRESSION ; PREGNANCY ; ESTRIOL ; ESR1
英文摘要:

This study sought to elucidate the role of the PvuII and XbaI polymorphisms of the estrogen receptor gene in 74 Chinese patients with multiple sclerosis, and 95 ethnicity-matched controls, using polymerase chain reaction-restriction fragment-length polymorphism analysis. The results revealed that the P allele of PvuII was significantly more prevalent in multiple sclerosis patients compared with controls (P = 0.019). While distribution frequencies were significantly increased in female multiple sclerosis patients compared with female controls (P = 0.044), no significant difference was observed between male patients and controls (P > 0.05). Frequencies of Ppxx genotypes were significantly higher in multiple sclerosis patients compared with controls (24.3% vs. 12.8%, P = 0.025). Genotypes and alleles of the estrogen receptor were not associated with age, number of attacks or expanded disability status scale scores of patients with multiple sclerosis. These findings indicate that the PvuII but not the XbaI polymorphism in the estrogen receptor gene is associated with susceptibility to multiple sclerosis in the Chinese population. In addition, women with P allele appear to be particularly susceptible to multiple sclerosis.

语种: 英语
所属项目编号: 81071148
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000294506000009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53431
Appears in Collections:北京大学第三临床医学院_神经内科_期刊论文

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作者单位: Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Qingli,Xie, Ruping,Fu, Yu,et al. Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis[J]. NEURAL REGENERATION RESEARCH,2011,6(19):1488-1492.
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