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学科主题临床医学
Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis
Sun, Qingli; Xie, Ruping; Fu, Yu; Li, Xiaogang; Fan, Dongsheng
关键词Estrogen Receptor Gene Polymorphism Multiple Sclerosis Case-control Study
刊名NEURAL REGENERATION RESEARCH
2011-07-01
DOI10.3969/j.issn.1673-5374.2011.19.009
6期:19页:1488-1492
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Neurosciences
研究领域[WOS]Cell Biology ; Neurosciences & Neurology
关键词[WOS]EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS ; DEMYELINATING DISEASE ; JAPANESE PATIENTS ; HUMAN-BREAST ; ALPHA ; ASSOCIATION ; EXPRESSION ; PREGNANCY ; ESTRIOL ; ESR1
英文摘要

This study sought to elucidate the role of the PvuII and XbaI polymorphisms of the estrogen receptor gene in 74 Chinese patients with multiple sclerosis, and 95 ethnicity-matched controls, using polymerase chain reaction-restriction fragment-length polymorphism analysis. The results revealed that the P allele of PvuII was significantly more prevalent in multiple sclerosis patients compared with controls (P = 0.019). While distribution frequencies were significantly increased in female multiple sclerosis patients compared with female controls (P = 0.044), no significant difference was observed between male patients and controls (P > 0.05). Frequencies of Ppxx genotypes were significantly higher in multiple sclerosis patients compared with controls (24.3% vs. 12.8%, P = 0.025). Genotypes and alleles of the estrogen receptor were not associated with age, number of attacks or expanded disability status scale scores of patients with multiple sclerosis. These findings indicate that the PvuII but not the XbaI polymorphism in the estrogen receptor gene is associated with susceptibility to multiple sclerosis in the Chinese population. In addition, women with P allele appear to be particularly susceptible to multiple sclerosis.

语种英语
WOS记录号WOS:000294506000009
项目编号81071148
资助机构National Natural Science Foundation of China
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53431
专题北京大学第三临床医学院_神经内科
作者单位Peking Univ, Hosp 3, Dept Neurol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Sun, Qingli,Xie, Ruping,Fu, Yu,et al. Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis[J]. NEURAL REGENERATION RESEARCH,2011,6(19):1488-1492.
APA Sun, Qingli,Xie, Ruping,Fu, Yu,Li, Xiaogang,&Fan, Dongsheng.(2011).Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis.NEURAL REGENERATION RESEARCH,6(19),1488-1492.
MLA Sun, Qingli,et al."Estrogen receptor gene polymorphism in a Chinese population with multiple sclerosis".NEURAL REGENERATION RESEARCH 6.19(2011):1488-1492.
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