IR@PKUHSC  > 北京大学第一临床医学院  > 心血管内科
学科主题临床医学
Long-Term Effects of Novel Biodegradable, Polymer-Coated, Sirolimus-Eluting Stents on Neointimal Formation in a Porcine Coronary Model
Peng, Hong-Yu2; Chen, Ming1; Zheng, Bo1; Wang, Xin-Gang1; Huo, Yong1
关键词Bioabsorbable Polymer Plga Sirolimus-eluting Stents Restenosis
刊名INTERNATIONAL HEART JOURNAL
2009-11-01
50期:6页:811-822
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
资助者Institute of Cardiovascular Research of Peking University First Hospital ; Institute of Cardiovascular Research of Peking University First Hospital
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]BALLOON ANGIOPLASTY ; RESTENOSIS ; PACLITAXEL ; IMPLANTATION ; ARTERIES ; INFLAMMATION ; DELIVERY ; RELEASE ; HUMANS ; INJURY
英文摘要

The postulated relationship between nonbiodegradable polymers and late stent thrombosis has led to a concerted effort to seek alternative biodegradable polymers for drug delivery. The purpose of this study Was to evaluate the long-term effects of novel sirolimuseluting stents (SES) with biodegradable polylactic-co-glycolic acid (PLGA) polymer oil neointimal thickening in a porcine coronary model. Three types of stents were implanted in different coronary arteries of the same mini-swine: bare cobalt-chromium stents (BMS); PLGA-coated-only stents (PCOS); and PLGA-coated, sirolimus-eluting stents (PCSES). A total of 26 animals underwent successful placement of 78 oversized stents (each stent-group, n = 26) in the coronary arteries with histopathologic analysis and Western blot at 28 days, 3 months, or 1 year. At 28 days and 3 months, the mean neointimal area was about two-fold lower in PCSES versus BMS or PCOS. At 1 year, the mean intinial area was similar for PCSES (1.76 +/- 0.28 mm(2)) and BMS (2.06 +/- 0.23 mm(2), P = 0.051). Western blot analysis demonstrated decreased expression of p27(kipl) in the vessel wall 3 months after PCSES implantation as compared with 28 days. PCSES effectively reduced in-stent neointimal formation for the first 3 months in this porcine coronary model. Beyond 3 months, neointimal proliferation was not substantially inhibited by PCSES. The observed delayed neointimal hyperplasia with PCSES may be partly related to the potential side effects of sirolimus and/or late insufficient arterial drug levels. (Int Heart J 2009; 50: 811-822)

语种英语
资助者Institute of Cardiovascular Research of Peking University First Hospital ; Institute of Cardiovascular Research of Peking University First Hospital
WOS记录号WOS:000273135500012
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53439
Collection北京大学第一临床医学院_心血管内科
作者单位1.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Hosp 1, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Peng, Hong-Yu,Chen, Ming,Zheng, Bo,et al. Long-Term Effects of Novel Biodegradable, Polymer-Coated, Sirolimus-Eluting Stents on Neointimal Formation in a Porcine Coronary Model[J]. INTERNATIONAL HEART JOURNAL,2009,50(6):811-822.
APA Peng, Hong-Yu,Chen, Ming,Zheng, Bo,Wang, Xin-Gang,&Huo, Yong.(2009).Long-Term Effects of Novel Biodegradable, Polymer-Coated, Sirolimus-Eluting Stents on Neointimal Formation in a Porcine Coronary Model.INTERNATIONAL HEART JOURNAL,50(6),811-822.
MLA Peng, Hong-Yu,et al."Long-Term Effects of Novel Biodegradable, Polymer-Coated, Sirolimus-Eluting Stents on Neointimal Formation in a Porcine Coronary Model".INTERNATIONAL HEART JOURNAL 50.6(2009):811-822.
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