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学科主题: 临床医学
题名:
Long-Term Effects of Novel Biodegradable, Polymer-Coated, Sirolimus-Eluting Stents on Neointimal Formation in a Porcine Coronary Model
作者: Peng, Hong-Yu2; Chen, Ming1; Zheng, Bo1; Wang, Xin-Gang1; Huo, Yong1
关键词: Bioabsorbable ; Polymer ; PLGA ; Sirolimus-eluting stents ; Restenosis
刊名: INTERNATIONAL HEART JOURNAL
发表日期: 2009-11-01
卷: 50, 期:6, 页:811-822
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: BALLOON ANGIOPLASTY ; RESTENOSIS ; PACLITAXEL ; IMPLANTATION ; ARTERIES ; INFLAMMATION ; DELIVERY ; RELEASE ; HUMANS ; INJURY
英文摘要:

The postulated relationship between nonbiodegradable polymers and late stent thrombosis has led to a concerted effort to seek alternative biodegradable polymers for drug delivery. The purpose of this study Was to evaluate the long-term effects of novel sirolimuseluting stents (SES) with biodegradable polylactic-co-glycolic acid (PLGA) polymer oil neointimal thickening in a porcine coronary model. Three types of stents were implanted in different coronary arteries of the same mini-swine: bare cobalt-chromium stents (BMS); PLGA-coated-only stents (PCOS); and PLGA-coated, sirolimus-eluting stents (PCSES). A total of 26 animals underwent successful placement of 78 oversized stents (each stent-group, n = 26) in the coronary arteries with histopathologic analysis and Western blot at 28 days, 3 months, or 1 year. At 28 days and 3 months, the mean neointimal area was about two-fold lower in PCSES versus BMS or PCOS. At 1 year, the mean intinial area was similar for PCSES (1.76 +/- 0.28 mm(2)) and BMS (2.06 +/- 0.23 mm(2), P = 0.051). Western blot analysis demonstrated decreased expression of p27(kipl) in the vessel wall 3 months after PCSES implantation as compared with 28 days. PCSES effectively reduced in-stent neointimal formation for the first 3 months in this porcine coronary model. Beyond 3 months, neointimal proliferation was not substantially inhibited by PCSES. The observed delayed neointimal hyperplasia with PCSES may be partly related to the potential side effects of sirolimus and/or late insufficient arterial drug levels. (Int Heart J 2009; 50: 811-822)

语种: 英语
项目资助者: Institute of Cardiovascular Research of Peking University First Hospital
WOS记录号: WOS:000273135500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53439
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Peking Univ, Dept Cardiol, Hosp 1, Beijing 100871, Peoples R China
2.Peking Univ, Inst Cardiovasc Res, Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Peng, Hong-Yu,Chen, Ming,Zheng, Bo,et al. Long-Term Effects of Novel Biodegradable, Polymer-Coated, Sirolimus-Eluting Stents on Neointimal Formation in a Porcine Coronary Model[J]. INTERNATIONAL HEART JOURNAL,2009,50(6):811-822.
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