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学科主题: 临床医学
题名:
Evaluation of human major histocompatibility complex class I chain-related A as a potential target for tumor imaging
作者: Tang, Bixia1,2; Yang, Zhi3; Huang, Jie1,2; Hao, Zhiyong1,2; Li, Wenjing1,2; Cui, Lianxian1,2; He, Wei1,2
关键词: MICA ; ovarian epithelial carcinoma ; antibody ; imaging ; technetium ; diagnosis
刊名: CANCER LETTERS
发表日期: 2008-05-08
DOI: 10.1016/j.canlet.2007.12.027
卷: 263, 期:1, 页:99-106
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: DELTA T-CELLS ; MALIGNANT DISEASES ; SOLUBLE MICA ; EXPRESSION ; NKG2D ; NEUROBLASTOMA ; CYTOTOXICITY ; RECOGNITION ; MONOVALENT ; ANTIBODIES
英文摘要:

To investigate the feasibility of using human major histocompatibility complex class I chain-related A (MICA) as a target for tumor imaging diagnosis, 10C6, a monoclonal antibody (mAb) that specifically recognizes MICA in vitro, was labeled with Tc-99m (technetium) and administered into mice bearing MICA-positive human ovarian epithelial carcinoma line SKOV3. Measurement of organ-specific radioactivity showed that tumor accumulated radioactivity continuously, while the uptake in the other organs decreased over time. Scintigram showed that the tumor became clearly visible at 24 h post-injection of radio-labeled 10C6 mAb. These results suggest that MICA is a promising target for tumor imaging and mAb 10C6 may be used clinically for early tumor diagnosis. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000255572700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53444
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Basic Med Sci, Dept Immunol, Beijing, Peoples R China
2.Peking Union Med Coll, Sch Basic Med, Beijing, Peoples R China
3.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing, Peoples R China

Recommended Citation:
Tang, Bixia,Yang, Zhi,Huang, Jie,et al. Evaluation of human major histocompatibility complex class I chain-related A as a potential target for tumor imaging[J]. CANCER LETTERS,2008,263(1):99-106.
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