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学科主题: 基础医学
题名:
Distinctly different expression of cytokines and chemokines in the lungs of two H5N1 avian influenza patients
作者: Deng, R.1; Lu, M.1; Korteweg, C.2; Gao, Z.1; McNutt, M. A.1; Ye, J.1; Zhang, T.3; Gu, J.1,3
关键词: human H5N1 influenza ; H5N1 autopsy lungs ; cytokine storm ; RT-PCR ; ELISA ; immunohistochemistry
刊名: JOURNAL OF PATHOLOGY
发表日期: 2008-11-01
DOI: 10.1002/path.2417
卷: 216, 期:3, 页:328-336
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Pathology
研究领域[WOS]: Oncology ; Pathology
关键词[WOS]: HUMAN-DISEASE ; VIRUSES ; PATHOGENESIS ; INFECTION ; RESPONSES ; MICE ; MACROPHAGES ; PATHOLOGY ; TISSUES ; HUMANS
英文摘要:

The pathogenesis of human H5N1 influenza remains poorly understood and controversial. ′Cytokine storm′ has been hypothesized to be the main cause of the severity of this disease. However, the significance of this hypothesis has been called into question by a recent report, which demonstrates that inhibition of the cytokine response did not protect against lethal H5N1 influenza infection in mice. Here we showed discrepant findings in two adult H5N1 autopsies and a fetus obtained at autopsy which also raise doubt about this hypothesis. Antigens of 10 cytokines/chemokines which were found to be significantly elevated in previous H5N1-infected patients and in vitro experiments, and mRNA of eight of these, were absent from the lungs of a pregnant woman and her fetus. In contrast, antigens of seven cytokines/chemokines and mRNA of six of these were found to be increased in the lungs of a male autopsy. The cells expressing these cytokines and chemokines were identified as type II pneumocytes, bronchial epithelial cells, macrophages and vascular endothelial cells. Levels of cytokines and chemokines in the serum of the male case were also significantly higher than those of infectious (infection other than by, H5N1) and non-infectious controls. In comparison with results from our previous study, it appeared that the male case had increased cytokine/chemokine expression but reduced viral load, while the pregnant female had diminished cytokine/chemokine expression but a significantly increased viral load in the lungs. These disparate findings in these two cases suggest that ′cytokine storm′ alone could not be a sufficient explanation for the severe lung injury of this newly emerging disease. Copyright (C) 2008 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 1307001
项目资助者: Ministry of Education, People&prime ; s Republic of China ; State Administration of Foreign Expert Affairs, People&prime ; s Republic of China ; Lifu Educational Foundation
WOS记录号: WOS:000260622000007
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53445
Appears in Collections:基础医学院_病理学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Infect Dis, Beijing 100871, Peoples R China
2.St Antonius Hosp, Dept Pulm Dis, NL-2430 EM Nieuwegein, Netherlands
3.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing, Peoples R China

Recommended Citation:
Deng, R.,Lu, M.,Korteweg, C.,et al. Distinctly different expression of cytokines and chemokines in the lungs of two H5N1 avian influenza patients[J]. JOURNAL OF PATHOLOGY,2008,216(3):328-336.
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