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学科主题: 基础医学
题名:
IN VITRO AND IN VIVO BIOCOMPATIBILITY STUDIES OF ZNO NANOPARTICLES
作者: Zheng, Yufeng1; Li, Ranzhong1; Wang, Yuedan2
关键词: ZnO ; biocompatibility ; cell proliferation ; apoptosis
刊名: INTERNATIONAL JOURNAL OF MODERN PHYSICS B
发表日期: 2009-03-20
卷: 23, 期:6-7, 页:1566-1571
收录类别: SCI ; ISTP
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Physics, Applied ; Physics, Condensed Matter ; Physics, Mathematical
研究领域[WOS]: Physics
英文摘要:

The in vitro and in vivo biocompatibility of the ZnO nanoparticles were evaluated using cell model and animal model, by MTT assay, flow cell cytometry, pathological optical and electron microscopy examinations. Both the L929 cell and Hela cell proliferative activity were strongly inhibited by the presence of ZnO nanoparticles, no matter cultured with low dose and high dose suspension. AnnexinV-FITC/PI-FCM assay showed that the number of necrotic cell and apoptotic cell increased significantly. Feeding the ZnO nanoparticle suspension through digestive tract would lead to the damage to some primary organs (heart, lung, liver and kidney). Further investigation by TEM showed the expanded sarcoplasmic reticulum and organelle vacuolation features.

语种: 英语
WOS记录号: WOS:000266134700130
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53450
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Dept Adv Mat & Nanotechnol, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Dept Immunol, Sch Basic Med, Beijing 100083, Peoples R China

Recommended Citation:
Zheng, Yufeng,Li, Ranzhong,Wang, Yuedan. IN VITRO AND IN VIVO BIOCOMPATIBILITY STUDIES OF ZNO NANOPARTICLES[J]. INTERNATIONAL JOURNAL OF MODERN PHYSICS B,2009,23(6-7):1566-1571.
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