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Echinacoside Elicits Endothelium-Dependent Relaxation in Rat Aortic Rings via an NO-cGMP Pathway
He, Wen-Jun1,2; Fang, Tai-Hui2; Ma, Xu1; Zhang, Ke1; Ma, Zhi-Zhong1; Tu, Peng-Fei1
关键词Echinacoside Endothelium-dependent No Thoracic Aorta Vasorelaxation
刊名PLANTA MEDICA
2009-10-01
DOI10.1055/s-0029-1185745
75期:13页:1400-1404
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]NITRIC-OXIDE ; PHENYLETHANOID GLYCOSIDES ; CISTANCHES-SALSA ; SMOOTH-MUSCLE ; L-ARGININE ; CELLS ; MECHANISMS ; CONTRACTION ; INHIBITION ; APOPTOSIS
英文摘要

The aim of this study was to identify and elucidate the vasorelaxant activity of echinacoside, a phenylethanoid glycoside isolated from the medicinal herb Cistanche tubulosa, and its possible underlying mechanism on isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 mu M) and KCI (60 mM). Echinacoside (30-300 mu M) exhibited an acute relaxation in endothelium-intact rings in a concentration-dependent manner, while this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of the endothelial nitric oxide synthase (eNOS) inhibitor, N-w-nitro-L-arginine methyl ester (L-NNA, 100 mu M), an unselective Soluble guanylate cyclase blocker, methylene blue (10 mu M), the selective sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 1 mu M); in addition, atropine (1 mu M), a selective muscarinic receptor antagonist, partially affected the relaxation. However, the cyclooxygenase inhibitor indomethacin (5 mu M) had no influence on the action. Echinacoside enhanced the cyclic guanosine monophosphate (cGMP) production in aortic rings contracted with PE. These results indicate for the first time that echinacoside mediates the endothelium-dependent vasodilator action in rat thoracic aortic rings through nitric oxide (NO)-cGMP pathway.

语种英语
WOS记录号WOS:000271577000005
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53452
专题北京大学药学院
北京大学基础医学院
北京大学药学院_天然药物学系
医学人文研究院/公共教学部_哲学与社会科学系
北京大学第三临床医学院_耳鼻喉科
作者单位1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100091, Peoples R China
2.Nanjing Univ Tradit Chinese Med, Dept Pharmacol, Nanjing, Peoples R China
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GB/T 7714
He, Wen-Jun,Fang, Tai-Hui,Ma, Xu,et al. Echinacoside Elicits Endothelium-Dependent Relaxation in Rat Aortic Rings via an NO-cGMP Pathway[J]. PLANTA MEDICA,2009,75(13):1400-1404.
APA He, Wen-Jun,Fang, Tai-Hui,Ma, Xu,Zhang, Ke,Ma, Zhi-Zhong,&Tu, Peng-Fei.(2009).Echinacoside Elicits Endothelium-Dependent Relaxation in Rat Aortic Rings via an NO-cGMP Pathway.PLANTA MEDICA,75(13),1400-1404.
MLA He, Wen-Jun,et al."Echinacoside Elicits Endothelium-Dependent Relaxation in Rat Aortic Rings via an NO-cGMP Pathway".PLANTA MEDICA 75.13(2009):1400-1404.
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