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学科主题: 药学
题名:
Echinacoside Elicits Endothelium-Dependent Relaxation in Rat Aortic Rings via an NO-cGMP Pathway
作者: He, Wen-Jun1,2; Fang, Tai-Hui2; Ma, Xu1; Zhang, Ke1; Ma, Zhi-Zhong1; Tu, Peng-Fei1
关键词: echinacoside ; endothelium-dependent ; NO ; thoracic aorta ; vasorelaxation
刊名: PLANTA MEDICA
发表日期: 2009-10-01
DOI: 10.1055/s-0029-1185745
卷: 75, 期:13, 页:1400-1404
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: NITRIC-OXIDE ; PHENYLETHANOID GLYCOSIDES ; CISTANCHES-SALSA ; SMOOTH-MUSCLE ; L-ARGININE ; CELLS ; MECHANISMS ; CONTRACTION ; INHIBITION ; APOPTOSIS
英文摘要:

The aim of this study was to identify and elucidate the vasorelaxant activity of echinacoside, a phenylethanoid glycoside isolated from the medicinal herb Cistanche tubulosa, and its possible underlying mechanism on isolated rat thoracic aortic rings pre-contracted with phenylephrine (PE, 1 mu M) and KCI (60 mM). Echinacoside (30-300 mu M) exhibited an acute relaxation in endothelium-intact rings in a concentration-dependent manner, while this relaxation was significantly inhibited in endothelium-denuded condition and in the presence of the endothelial nitric oxide synthase (eNOS) inhibitor, N-w-nitro-L-arginine methyl ester (L-NNA, 100 mu M), an unselective Soluble guanylate cyclase blocker, methylene blue (10 mu M), the selective sGC inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (ODQ, 1 mu M); in addition, atropine (1 mu M), a selective muscarinic receptor antagonist, partially affected the relaxation. However, the cyclooxygenase inhibitor indomethacin (5 mu M) had no influence on the action. Echinacoside enhanced the cyclic guanosine monophosphate (cGMP) production in aortic rings contracted with PE. These results indicate for the first time that echinacoside mediates the endothelium-dependent vasodilator action in rat thoracic aortic rings through nitric oxide (NO)-cGMP pathway.

语种: 英语
所属项目编号: 30472070
项目资助者: National Natural Science Foundation of China.
WOS记录号: WOS:000271577000005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53452
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100091, Peoples R China
2.Nanjing Univ Tradit Chinese Med, Dept Pharmacol, Nanjing, Peoples R China

Recommended Citation:
He, Wen-Jun,Fang, Tai-Hui,Ma, Xu,et al. Echinacoside Elicits Endothelium-Dependent Relaxation in Rat Aortic Rings via an NO-cGMP Pathway[J]. PLANTA MEDICA,2009,75(13):1400-1404.
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