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学科主题: 基础医学
题名:
Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation
作者: Li, Ting; Zhong, Ji; Chen, Yingyu; Qiu, Xiaoyan; Zhang, Ting; Ma, Dalong; Han, Wenling
关键词: CKLFSF ; CKLF1 ; kinetic expression ; T lymphocyte activation ; PHA
刊名: LIFE SCIENCES
发表日期: 2006-07-04
DOI: 10.1016/j.lfs.2006.01.042
卷: 79, 期:6, 页:519-524
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]: Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]: CYTOKINE GENE-EXPRESSION ; RHEUMATOID-ARTHRITIS ; IN-VITRO ; DISEASE ; INFLAMMATION ; CLONING ; LIGAND ; BLOOD ; CELLS ; MODEL
英文摘要:

Chemokine-like factor I (CKLF1) is a cytokine with chemotactic effects on leukocytes and a functional ligand of CCR4. This cytokine is widely expressed and the level of expression is reported to be upregulated in asthma and rheumatoid arthritis (RA), disease conditions in which T lymphocytes are over-activated. In order to determine the expression profile of CKLF1 in activated T lymphocytes, we first employed a PCR-based method on human blood fractions cDNA panels and found that CKLF1 was upregulated in activated CD4+ and CD8+ cells, with no obvious changes in CD19+ cells. We further performed kinetic analyses of CKLF1 expression in phytohemagglutinin (PHA)-stimulated human peripheral blood lymphocytes (PBL) at both the mRNA and protein levels. In resting PBL, the constitutive expression of CKLF1 was low at mRNA level and barely detectable at the protein level; however, both were remarkably upregulated by PHA, appearing at 8h after PHA-stimulation and persisting up to 72 h. These results suggest that CKLF1 may be involved in T lymphocyte activation and further study of CKLF1 function will prove valuable. (c) 2006 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000238777400002
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53454
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China

Recommended Citation:
Li, Ting,Zhong, Ji,Chen, Yingyu,et al. Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation[J]. LIFE SCIENCES,2006,79(6):519-524.
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