学科主题基础医学
Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation
Li, Ting; Zhong, Ji; Chen, Yingyu; Qiu, Xiaoyan; Zhang, Ting; Ma, Dalong; Han, Wenling
关键词CKLFSF CKLF1 kinetic expression T lymphocyte activation PHA
刊名LIFE SCIENCES
2006-07-04
DOI10.1016/j.lfs.2006.01.042
79期:6页:519-524
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental ; Pharmacology & Pharmacy
研究领域[WOS]Research & Experimental Medicine ; Pharmacology & Pharmacy
关键词[WOS]CYTOKINE GENE-EXPRESSION ; RHEUMATOID-ARTHRITIS ; IN-VITRO ; DISEASE ; INFLAMMATION ; CLONING ; LIGAND ; BLOOD ; CELLS ; MODEL
英文摘要

Chemokine-like factor I (CKLF1) is a cytokine with chemotactic effects on leukocytes and a functional ligand of CCR4. This cytokine is widely expressed and the level of expression is reported to be upregulated in asthma and rheumatoid arthritis (RA), disease conditions in which T lymphocytes are over-activated. In order to determine the expression profile of CKLF1 in activated T lymphocytes, we first employed a PCR-based method on human blood fractions cDNA panels and found that CKLF1 was upregulated in activated CD4+ and CD8+ cells, with no obvious changes in CD19+ cells. We further performed kinetic analyses of CKLF1 expression in phytohemagglutinin (PHA)-stimulated human peripheral blood lymphocytes (PBL) at both the mRNA and protein levels. In resting PBL, the constitutive expression of CKLF1 was low at mRNA level and barely detectable at the protein level; however, both were remarkably upregulated by PHA, appearing at 8h after PHA-stimulation and persisting up to 72 h. These results suggest that CKLF1 may be involved in T lymphocyte activation and further study of CKLF1 function will prove valuable. (c) 2006 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000238777400002
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53454
专题北京大学基础医学院_北京大学人类疾病基因研究中心
作者单位1.Peking Univ, Ctr Human Dis Genom, Beijing 100083, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Lab Med Immunol, Beijing 100083, Peoples R China
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Li, Ting,Zhong, Ji,Chen, Yingyu,et al. Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation[J]. LIFE SCIENCES,2006,79(6):519-524.
APA Li, Ting.,Zhong, Ji.,Chen, Yingyu.,Qiu, Xiaoyan.,Zhang, Ting.,...&Han, Wenling.(2006).Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation.LIFE SCIENCES,79(6),519-524.
MLA Li, Ting,et al."Expression of chemokine-like factor 1 is upregulated during T lymphocyte activation".LIFE SCIENCES 79.6(2006):519-524.
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