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Applying Imaging Genetics to ADHD: the Promises and the Challenges
Wu, Zhaomin1,2; Yang, Li1,2; Wang, Yufeng1,2
关键词Neuroimaging Genetics Adhd
刊名MOLECULAR NEUROBIOLOGY
2014-10-01
DOI10.1007/s12035-014-8683-z
50期:2页:449-462
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]ATTENTION-DEFICIT/HYPERACTIVITY DISORDER ; GENOME-WIDE ASSOCIATION ; DEFICIT HYPERACTIVITY DISORDER ; DOPAMINE TRANSPORTER GENOTYPE ; WHITE-MATTER MICROSTRUCTURE ; CORTICAL SURFACE-AREA ; NITRIC-OXIDE SYNTHASE ; ADULT ADHD ; ALZHEIMERS-DISEASE ; MOLECULAR-GENETICS
英文摘要

Attention deficit/hyperactivity disorder (ADHD) is one of the most prevalent childhood psychiatric disorders. During the past decades, studies have focused on its genetic background and the abnormality of the brain structure and function. Recently, an advanced technique linking these two areas, namely, the imaging genetics emerged and kept growing. Imaging genetics primarily identifies genes that influence the brain variations. There are three main strategies of doing an imaging genetic study: using neuroimaging as endophenotypes to find the associated DNA variants, finding neuroimaging effects of risk genes, and hypothesis-free whole-brain voxelwise genome-wide association study. In this review, we begin with demonstrating the basic principles of imaging genetics precisely, with examples from other psychiatric conditions, and then go on to synthesize the existing imaging genetic studies in ADHD. Finally, we elaborate the challenges of applying imaging genetics to ADHD. We conclude that imaging genetics has somewhat showed its potential to provide a more precise understanding of how the genes shape the brain variations and further the clinical features of ADHD.

语种英语
WOS记录号WOS:000343157900015
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53457
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Hosp 6, Beijing 100871, Peoples R China
2.Minist Hlth, Key Lab Mental Hlth, Beijing, Peoples R China
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GB/T 7714
Wu, Zhaomin,Yang, Li,Wang, Yufeng. Applying Imaging Genetics to ADHD: the Promises and the Challenges[J]. MOLECULAR NEUROBIOLOGY,2014,50(2):449-462.
APA Wu, Zhaomin,Yang, Li,&Wang, Yufeng.(2014).Applying Imaging Genetics to ADHD: the Promises and the Challenges.MOLECULAR NEUROBIOLOGY,50(2),449-462.
MLA Wu, Zhaomin,et al."Applying Imaging Genetics to ADHD: the Promises and the Challenges".MOLECULAR NEUROBIOLOGY 50.2(2014):449-462.
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