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Pulmonary toxicity and translocation of nanodiamonds in mice
Yuan, Yuan1; Wang, Xiang2; Jia, Guang2; Liu, Jia-Hui1; Wang, Tiancheng3; Gu, Yiqun4; Yang, Sheng-Tao1; Zhen, Sen2; Wang, Haifang1,5; Liu, Yuanfang1,5
关键词Nanodiamond Pulmonary Toxicity Intratracheal Instillation Translocation
刊名DIAMOND AND RELATED MATERIALS
2010-04-01
DOI10.1016/j.diamond.2009.11.022
19期:4页:291-299
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Materials Science, Multidisciplinary
资助者China Natural Science Foundation ; China Ministry of Science and Technology ; China Natural Science Foundation ; China Ministry of Science and Technology
研究领域[WOS]Materials Science
关键词[WOS]WALL CARBON NANOTUBES ; DIAMOND NANOPARTICLES ; INTRATRACHEAL INSTILLATION ; FLUORESCENT NANODIAMONDS ; INHALED NANOPARTICLES ; BLOOD-CIRCULATION ; PARTICLES ; DELIVERY ; RATS ; DEPOSITION
英文摘要

Because of the possible health threat of nanodiamonds (NDs) to organisms, the pulmonary toxicity and translocation of NDs in different sizes in mice were investigated after intratracheal instillation administration. Biochemical assays, ultrastructural and histopathological evaluations of the lungs of the control and the ND exposed mice were carried out at 1, 7, 14 or 28 days post-exposure. Exposure to 1.0 mg/kg NDs with an average diameter of 4 nm produced a temporary lung index increase at 1 day post-exposure. NDs did not have evident adverse effects in the lungs within the studied period according to histopathological and ultrastructural investigations. Furthermore, no lipid peroxidation of the lung was observed. On the whole, intratracheally instilled NDs are of low pulmonary toxicity. In addition, the amount of NDs in alveolar decreased with time elapsed and the macrophages burdened with NDs were clearly observed in the bronchia from 1 day to 28 days post-exposure. Thus we affirm the critical role of alveolar macrophages in the main excretion pathway of NDs from the lungs, i.e. they engulf the NDs, migrate upward to the trachea by escalator/mucociliary system and finally enter the pharynx. (C) 2009 Elsevier B.V. All rights reserved.

语种英语
所属项目编号20871010 ; 200603705604 ; 200903930303
资助者China Natural Science Foundation ; China Ministry of Science and Technology ; China Natural Science Foundation ; China Ministry of Science and Technology
WOS记录号WOS:000276130000005
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53459
专题北京大学公共卫生学院
作者单位1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Matern Hosp Haidian Dist, Beijing 100080, Peoples R China
3.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
4.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China
5.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Yuan,Wang, Xiang,Jia, Guang,et al. Pulmonary toxicity and translocation of nanodiamonds in mice[J]. DIAMOND AND RELATED MATERIALS,2010,19(4):291-299.
APA Yuan, Yuan.,Wang, Xiang.,Jia, Guang.,Liu, Jia-Hui.,Wang, Tiancheng.,...&Liu, Yuanfang.(2010).Pulmonary toxicity and translocation of nanodiamonds in mice.DIAMOND AND RELATED MATERIALS,19(4),291-299.
MLA Yuan, Yuan,et al."Pulmonary toxicity and translocation of nanodiamonds in mice".DIAMOND AND RELATED MATERIALS 19.4(2010):291-299.
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