学科主题基础医学
Mechanism of interleukin-1 beta-induced calcitonin gene-related peptide production from dorsal root ganglion neurons of neonatal rats
Hou, LF; Li, WJ; Wang, X
关键词interleukin-1 beta calcitonin gene-related peptide dorsal root ganglion
刊名JOURNAL OF NEUROSCIENCE RESEARCH
2003-07-15
DOI10.1002/jnr.10651
73期:2页:188-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]PRIMARY SENSORY NEURONS ; NECROSIS-FACTOR-ALPHA ; CGRP MESSENGER-RNAS ; SPINAL-CORD ; SUBSTANCE-P ; BETA-CGRP ; DIFFERENTIAL EXPRESSION ; PERIPHERAL INFLAMMATION ; NERVOUS-SYSTEM ; NEUROPEPTIDE
英文摘要

Calcitonin gene-related peptide (CGRP) is synthesized in dorsal root ganglion (DRG) neurons and released from primary afferent neurons to mediate hemodynamic effects and neurogenic inflammation. The effect of the proinflammatory cytokine interleukin-1 (IL-1)-beta on CGRP release from these sensory neurons was investigated. The results showed that IL-1beta (1 ng/ml) could directly induce CGRP release following prolonged incubation (24 hr) with these neurons. Treatment with IL-1beta (0.1-1.0 ng/ml) significantly increased CGRP release in a concentration-dependent manner. In addition, pretreatment of DRG cells with actinomycin D at 1 muM or cyclohexamide at 10 muM for 30 min inhibited 1 ng/ml IL-1beta-induced CGRP release in DRG neurons of neonatal rats. The inhibitors of PKC, JNK MAPK and NF-kappaB, but not p38 or ERK1/2 MAPK, blocked IL-1beta-induced CGRP release. RNase protection assay showed that IL-1beta could cause alpha-CGRP mRNA increase in a time- and concentration-dependent manner, although the level of P-CGRP mRNA was not affected. These results indicate that IL-1beta may activate PKC, which in turn initiates JNK MAPK and activates NF-kappaB and finally induces alpha-CGRP gene expression and release from these sensory neurons. (C) 2003 Wiley-Liss, Inc.

语种英语
WOS记录号WOS:000183930200005
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被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53465
专题北京大学基础医学院_生理学与病理生理学系
作者单位1.Peking Univ, Dept Physiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China
3.Peking Univ, Reference Lab Educ Minist Mol Cardiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
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GB/T 7714
Hou, LF,Li, WJ,Wang, X. Mechanism of interleukin-1 beta-induced calcitonin gene-related peptide production from dorsal root ganglion neurons of neonatal rats[J]. JOURNAL OF NEUROSCIENCE RESEARCH,2003,73(2):188-197.
APA Hou, LF,Li, WJ,&Wang, X.(2003).Mechanism of interleukin-1 beta-induced calcitonin gene-related peptide production from dorsal root ganglion neurons of neonatal rats.JOURNAL OF NEUROSCIENCE RESEARCH,73(2),188-197.
MLA Hou, LF,et al."Mechanism of interleukin-1 beta-induced calcitonin gene-related peptide production from dorsal root ganglion neurons of neonatal rats".JOURNAL OF NEUROSCIENCE RESEARCH 73.2(2003):188-197.
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