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学科主题基础医学
Effects of morphine on rheological properties of rat red blood cells
Nie, X; Wen, ZY; Yan, ZY; Huang, LX; Sun, DG; Cheng, BJ
关键词Morphine Hemorheology Ektacytometry Red Blood Cell Membrane Fluidity Deformability Orientation Index (Di)(Or) Small Deformation Index (Di)(d) Membrane Secondary Structure
刊名CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
2000
22期:3页:189-195
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Peripheral Vascular Disease
研究领域[WOS]Hematology ; Cardiovascular System & Cardiology
关键词[WOS]SHEAR-FLOW FIELD ; LOW-VISCOSITY ; RBC MEMBRANE ; IN-VITRO ; ORIENTATION ; FLUIDITY
英文摘要

To evaluate the effect of morphine on red blood cells, in vivo and in vitro rat models of morphine dependence were established. Rheological properties of rat red cells were measured by ektacytometry; the biophysical changes in the membrane of rat red cells were measured by the Fourier-Transformed Infrared technique (FT-IR) and the fluorescence depolarization method. The results show that the membrane fluidity of red cells was greatly reduced by morphine and the secondary structure of membrane proteins was changed. This suggests that morphine affects the rat red cell membrane directly, rather than through opioids-receptors.

语种英语
WOS记录号WOS:000088168200003
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53467
专题北京大学基础医学院_生物物理学系
作者单位1.Beijing Med Univ, Dept Med Phys, Hemorheol Ctr, Beijing 100083, Peoples R China
2.Beijing Med Univ, Dept Biophys, Beijing 100083, Peoples R China
3.Peking Univ, Dept Engn Sci & Mech, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Nie, X,Wen, ZY,Yan, ZY,et al. Effects of morphine on rheological properties of rat red blood cells[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2000,22(3):189-195.
APA Nie, X,Wen, ZY,Yan, ZY,Huang, LX,Sun, DG,&Cheng, BJ.(2000).Effects of morphine on rheological properties of rat red blood cells.CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,22(3),189-195.
MLA Nie, X,et al."Effects of morphine on rheological properties of rat red blood cells".CLINICAL HEMORHEOLOGY AND MICROCIRCULATION 22.3(2000):189-195.
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