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学科主题: 基础医学
题名:
Effects of morphine on rheological properties of rat red blood cells
作者: Nie, X; Wen, ZY; Yan, ZY; Huang, LX; Sun, DG; Cheng, BJ
关键词: morphine ; hemorheology ; ektacytometry ; red blood cell ; membrane fluidity ; deformability ; orientation index (DI)(or) ; small deformation index (DI)(d) ; membrane secondary structure
刊名: CLINICAL HEMORHEOLOGY AND MICROCIRCULATION
发表日期: 2000
卷: 22, 期:3, 页:189-195
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Peripheral Vascular Disease
研究领域[WOS]: Hematology ; Cardiovascular System & Cardiology
关键词[WOS]: SHEAR-FLOW FIELD ; LOW-VISCOSITY ; RBC MEMBRANE ; IN-VITRO ; ORIENTATION ; FLUIDITY
英文摘要:

To evaluate the effect of morphine on red blood cells, in vivo and in vitro rat models of morphine dependence were established. Rheological properties of rat red cells were measured by ektacytometry; the biophysical changes in the membrane of rat red cells were measured by the Fourier-Transformed Infrared technique (FT-IR) and the fluorescence depolarization method. The results show that the membrane fluidity of red cells was greatly reduced by morphine and the secondary structure of membrane proteins was changed. This suggests that morphine affects the rat red cell membrane directly, rather than through opioids-receptors.

语种: 英语
WOS记录号: WOS:000088168200003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53467
Appears in Collections:基础医学院_生物物理学系_期刊论文

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作者单位: 1.Beijing Med Univ, Dept Med Phys, Hemorheol Ctr, Beijing 100083, Peoples R China
2.Beijing Med Univ, Dept Biophys, Beijing 100083, Peoples R China
3.Peking Univ, Dept Engn Sci & Mech, Beijing 100871, Peoples R China

Recommended Citation:
Nie, X,Wen, ZY,Yan, ZY,et al. Effects of morphine on rheological properties of rat red blood cells[J]. CLINICAL HEMORHEOLOGY AND MICROCIRCULATION,2000,22(3):189-195.
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