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Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin
Wang, Xiang1; Yao, Shuqiao1; Kirkpatrick, Brian2; Shi, Chuan3; Yi, Jinyao1
关键词Deficit Schizophrenia Nondeficit Schizophrenia Psychopathology Neurocognitive Functioning
刊名PSYCHIATRY RESEARCH
2008-03-15
DOI10.1016/j.psychres.2006.09.007
158期:2页:195-205
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]MEDIAL PREFRONTAL CORTEX ; PURSUIT EYE-MOVEMENTS ; CEREBRAL-BLOOD-FLOW ; IV FIELD TRIAL ; NEGATIVE SYMPTOMS ; INTERSTITIAL-CELLS ; TRACKING DISORDER ; WHITE-MATTER ; IDENTIFICATION ; FORMS
英文摘要

Deficit schizophrenia is a relatively homogeneous subtype of patients which is considered helpful to explore the pathogenesis of schizophrenia. The aim of the present study was to reexamine the clinical characteristics of deficit (n=30) and nondeficit schizophrenia (n=93) in a Chinese sample and investigate the differences of neurocognitive function among the two Subtypes of schizophrenia and the normal controls (n=103). Schizophrenia patients completed the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS) and Scale for the Assessment of Positive Symptoms (SAPS). Additionally, all participants completed an abbreviated version of the Wechsler Adult Intelligence Scale (WAIS-RC) and a neuropsychological test battery examining the executive functions, visuopatial abilities and explicit memory related to the frontal, parietal, and temporal lobe functions. The deficit group received higher scores than the nondeficit group Oil the BPRS anergia factor and SANS affective flattening, alogia, avolition-apathy, anhedonia-asociality subscales, but not on the SAPS. Both two schizophrenia subgroups performed more poorly on the WAIS-RC and neuropsychological tests than the normal controls. Moreover, deficit patients performed worse than nondeficit patients on the prorated IQ, the Trail Making Test, Wisconsin Card Sorting test and Block Design test. The present Study replicated symptom profiles in deficit vs. nondeficit schizophrenia in the Chinese sample. Furthermore, this study Suggested that deficit schizophrenia is associated with frontal and parietal lobe impairment, and that temporal lobe dysfunction may be a common basis for cognitive impairment in schizophrenia as a whole. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000254913600010
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被引频次:31[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53472
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Cent S Univ, Xiangya Hosp 2, Med Psychol Res Ctr, Changsha 410011, Hunan, Peoples R China
2.Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA
3.Peking Univ, Mental Hlth Inst, Beijing 100083, Peoples R China
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GB/T 7714
Wang, Xiang,Yao, Shuqiao,Kirkpatrick, Brian,et al. Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin[J]. PSYCHIATRY RESEARCH,2008,158(2):195-205.
APA Wang, Xiang,Yao, Shuqiao,Kirkpatrick, Brian,Shi, Chuan,&Yi, Jinyao.(2008).Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin.PSYCHIATRY RESEARCH,158(2),195-205.
MLA Wang, Xiang,et al."Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin".PSYCHIATRY RESEARCH 158.2(2008):195-205.
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