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学科主题: 精神卫生
题名:
Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin
作者: Wang, Xiang1; Yao, Shuqiao1; Kirkpatrick, Brian2; Shi, Chuan3; Yi, Jinyao1
关键词: deficit schizophrenia ; nondeficit schizophrenia ; psychopathology ; neurocognitive functioning
刊名: PSYCHIATRY RESEARCH
发表日期: 2008-03-15
DOI: 10.1016/j.psychres.2006.09.007
卷: 158, 期:2, 页:195-205
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Psychiatry
研究领域[WOS]: Psychiatry
关键词[WOS]: MEDIAL PREFRONTAL CORTEX ; PURSUIT EYE-MOVEMENTS ; CEREBRAL-BLOOD-FLOW ; IV FIELD TRIAL ; NEGATIVE SYMPTOMS ; INTERSTITIAL-CELLS ; TRACKING DISORDER ; WHITE-MATTER ; IDENTIFICATION ; FORMS
英文摘要:

Deficit schizophrenia is a relatively homogeneous subtype of patients which is considered helpful to explore the pathogenesis of schizophrenia. The aim of the present study was to reexamine the clinical characteristics of deficit (n=30) and nondeficit schizophrenia (n=93) in a Chinese sample and investigate the differences of neurocognitive function among the two Subtypes of schizophrenia and the normal controls (n=103). Schizophrenia patients completed the Brief Psychiatric Rating Scale (BPRS), Scale for the Assessment of Negative Symptoms (SANS) and Scale for the Assessment of Positive Symptoms (SAPS). Additionally, all participants completed an abbreviated version of the Wechsler Adult Intelligence Scale (WAIS-RC) and a neuropsychological test battery examining the executive functions, visuopatial abilities and explicit memory related to the frontal, parietal, and temporal lobe functions. The deficit group received higher scores than the nondeficit group Oil the BPRS anergia factor and SANS affective flattening, alogia, avolition-apathy, anhedonia-asociality subscales, but not on the SAPS. Both two schizophrenia subgroups performed more poorly on the WAIS-RC and neuropsychological tests than the normal controls. Moreover, deficit patients performed worse than nondeficit patients on the prorated IQ, the Trail Making Test, Wisconsin Card Sorting test and Block Design test. The present Study replicated symptom profiles in deficit vs. nondeficit schizophrenia in the Chinese sample. Furthermore, this study Suggested that deficit schizophrenia is associated with frontal and parietal lobe impairment, and that temporal lobe dysfunction may be a common basis for cognitive impairment in schizophrenia as a whole. (C) 2006 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000254913600010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53472
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Cent S Univ, Xiangya Hosp 2, Med Psychol Res Ctr, Changsha 410011, Hunan, Peoples R China
2.Med Coll Georgia, Dept Psychiat & Hlth Behav, Augusta, GA 30912 USA
3.Peking Univ, Mental Hlth Inst, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Xiang,Yao, Shuqiao,Kirkpatrick, Brian,et al. Psychopathology and neuropsychological impairments in deficit and nondeficit schizophrenia of Chinese origin[J]. PSYCHIATRY RESEARCH,2008,158(2):195-205.
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