IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科
学科主题临床医学
Interference of antimodified C-reactive protein autoantibodies from lupus nephritis in the biofunctions of modified C-reactive protein
Yang, Xiao-wei1,2,3,4; Tan, Ying1,2,3,4; Yu, Feng1,2,3,4; Zhao, Ming-hui1,2,3,4
关键词Sle Lupus Nephritis Anti-mcrp Autoantibodies Complements Apoptosis
刊名HUMAN IMMUNOLOGY
2012-02-01
DOI10.1016/j.humimm.2011.12.007
73期:2页:156-163
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology
研究领域[WOS]Immunology
关键词[WOS]MANNOSE-BINDING LECTIN ; APOPTOTIC CELLS ; FACTOR-H ; COMPLEMENT ACTIVATION ; DISEASE-ACTIVITY ; HUMAN-NEUTROPHILS ; SERUM-LEVELS ; 2 PARTS ; ERYTHEMATOSUS ; CRP
英文摘要

Autoantibodies against modified C-reactive protein (mCRP) are frequently found in patients with lupus nephritis and are associated with disease activity, suggesting their pathogenic role in lupus nephritis. The aim of this study was to investigate the influence of anti-mCRP autoantibodies from patients with lupus nephritis on the biofunctions of mCRP. mCRP plays important roles in the clearance of apoptotic cells and immune complex-mediated injuries via binding to C1q and factor H and acting as an opsonin. In this study, we confirmed that mCRP could bind to C1q and factor H, and the binding between mCRP and C1q was mainly via the collagen-like region of C1q by enzyme-linked immunosorbent assay and surface plasmon resonance. mCRP could significantly enhance the phagocytosis of late apoptotic cells in the presence of normal human serum. Autoantibodies against mCRP, purified from immunoglobulin G fractions of 3 patients with lupus nephritis by affinity chromatography, could significantly inhibit the binding between mCRP and C1q or factor H and reduce the clearance of late apoptotic cells enhanced by mCRP. Our observations suggest that anti-mCRP autoantibodies from patients with lupus nephritis might be pathogenic in systemic lupus erythematosus and lupus nephritis through interfering with the biofunctions of mCRP. (C) 2012 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000300123200003
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53478
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Peking Univ, Dept Med, Div Renal, Hosp 1, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Hlth China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yang, Xiao-wei,Tan, Ying,Yu, Feng,et al. Interference of antimodified C-reactive protein autoantibodies from lupus nephritis in the biofunctions of modified C-reactive protein[J]. HUMAN IMMUNOLOGY,2012,73(2):156-163.
APA Yang, Xiao-wei,Tan, Ying,Yu, Feng,&Zhao, Ming-hui.(2012).Interference of antimodified C-reactive protein autoantibodies from lupus nephritis in the biofunctions of modified C-reactive protein.HUMAN IMMUNOLOGY,73(2),156-163.
MLA Yang, Xiao-wei,et al."Interference of antimodified C-reactive protein autoantibodies from lupus nephritis in the biofunctions of modified C-reactive protein".HUMAN IMMUNOLOGY 73.2(2012):156-163.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Xiao-wei]的文章
[Tan, Ying]的文章
[Yu, Feng]的文章
百度学术
百度学术中相似的文章
[Yang, Xiao-wei]的文章
[Tan, Ying]的文章
[Yu, Feng]的文章
必应学术
必应学术中相似的文章
[Yang, Xiao-wei]的文章
[Tan, Ying]的文章
[Yu, Feng]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。