学科主题基础医学
Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice
Hou, Rong1,2,3; Ohtsuji, Mareki4; Ohtsuji, Naomi4; Zhang, Li1,2,5; Adachi, Takahiro1,2,3; Hirose, Sachiko4; Tsubata, Takeshi1,2,3
关键词Diabetes NOD mice Insulitis CD72 Congenic mouse
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2009-02-27
DOI10.1016/j.bbrc.2009.01.072
380期:1页:193-197
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]NOD MOUSE ; B-CELLS ; SUSCEPTIBILITY ; INSULITIS ; MELLITUS ; PAX5
英文摘要

The nonobese diabetic (NOD) mouse is a useful model of autoimmune type 1 diabetes exhibiting many similarities to human type 1 diabetes patients including the presence of auto-reactive T cells and pancreas-specific autoantiboies. Multiple Idd loci control the development of diabetes in NOD mice. CD72, a B cell membrane-bound glycoprotein carrying a C-type lectin-like domain, is all inhibitory co-receptor of the B cell antigen receptor (BCR) that negatively regulates BCR signaling. Among four known haplotypes of mouse CD72, NOD mice carry the CD72(c) haplotype, whereas most of the other inbred strains of mice carry either CD72(a) OF CD72(b). In this study, we generated congenic NOD.CD72(b) mice that Carry C57BL/6 (B6) mouse-derived centromeric chromosome 4 interval (24-45 cM) Surrounding the CD72(b) locus. Unexpectedly, NOD.CD72(b) mice were not protected from diabetes, but rather exhibited accelerated development of both insulitis and diabetes. Our result defines novel locus or loci in the vicinity of CD72 gene that negatively control diabetes, indicating that NOD disease is under complex genetic controls of not only Idd genes but also disease-resistant genes. (C) 2009 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000263656100036
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53479
专题北京大学基础医学院_北京大学人类疾病基因研究中心
作者单位1.Tokyo Med & Dent Univ, Sch Biomed Sci, Immunol Lab, Bunkyo Ku, Tokyo 1138510, Japan
2.Tokyo Med & Dent Univ, Med Res Inst, Dept Immunol, Bunkyo Ku, Tokyo 1138510, Japan
3.Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan
4.Juntendo Univ, Sch Med, Dept Pathol, Bunkyo Ku, Tokyo 1138421, Japan
5.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Hou, Rong,Ohtsuji, Mareki,Ohtsuji, Naomi,et al. Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,380(1):193-197.
APA Hou, Rong.,Ohtsuji, Mareki.,Ohtsuji, Naomi.,Zhang, Li.,Adachi, Takahiro.,...&Tsubata, Takeshi.(2009).Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,380(1),193-197.
MLA Hou, Rong,et al."Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 380.1(2009):193-197.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Centromeric interval(265KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hou, Rong]的文章
[Ohtsuji, Mareki]的文章
[Ohtsuji, Naomi]的文章
百度学术
百度学术中相似的文章
[Hou, Rong]的文章
[Ohtsuji, Mareki]的文章
[Ohtsuji, Naomi]的文章
必应学术
必应学术中相似的文章
[Hou, Rong]的文章
[Ohtsuji, Mareki]的文章
[Ohtsuji, Naomi]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Centromeric interval of chromosome 4 derived from C57BL6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。