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学科主题: 基础医学
题名:
Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice
作者: Hou, Rong1,2,3; Ohtsuji, Mareki4; Ohtsuji, Naomi4; Zhang, Li1,2,5; Adachi, Takahiro1,2,3; Hirose, Sachiko4; Tsubata, Takeshi1,2,3
关键词: Diabetes ; NOD mice ; Insulitis ; CD72 ; Congenic mouse
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2009-02-27
DOI: 10.1016/j.bbrc.2009.01.072
卷: 380, 期:1, 页:193-197
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: NOD MOUSE ; B-CELLS ; SUSCEPTIBILITY ; INSULITIS ; MELLITUS ; PAX5
英文摘要:

The nonobese diabetic (NOD) mouse is a useful model of autoimmune type 1 diabetes exhibiting many similarities to human type 1 diabetes patients including the presence of auto-reactive T cells and pancreas-specific autoantiboies. Multiple Idd loci control the development of diabetes in NOD mice. CD72, a B cell membrane-bound glycoprotein carrying a C-type lectin-like domain, is all inhibitory co-receptor of the B cell antigen receptor (BCR) that negatively regulates BCR signaling. Among four known haplotypes of mouse CD72, NOD mice carry the CD72(c) haplotype, whereas most of the other inbred strains of mice carry either CD72(a) OF CD72(b). In this study, we generated congenic NOD.CD72(b) mice that Carry C57BL/6 (B6) mouse-derived centromeric chromosome 4 interval (24-45 cM) Surrounding the CD72(b) locus. Unexpectedly, NOD.CD72(b) mice were not protected from diabetes, but rather exhibited accelerated development of both insulitis and diabetes. Our result defines novel locus or loci in the vicinity of CD72 gene that negatively control diabetes, indicating that NOD disease is under complex genetic controls of not only Idd genes but also disease-resistant genes. (C) 2009 Elsevier Inc. All rights reserved.

语种: 英语
WOS记录号: WOS:000263656100036
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53479
Appears in Collections:基础医学院_北京大学人类疾病基因研究中心_期刊论文

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作者单位: 1.Tokyo Med & Dent Univ, Sch Biomed Sci, Immunol Lab, Bunkyo Ku, Tokyo 1138510, Japan
2.Tokyo Med & Dent Univ, Med Res Inst, Dept Immunol, Bunkyo Ku, Tokyo 1138510, Japan
3.Japan Sci & Technol Agcy, Core Res Evolut Sci & Technol, Kawaguchi, Saitama 3320012, Japan
4.Juntendo Univ, Sch Med, Dept Pathol, Bunkyo Ku, Tokyo 1138421, Japan
5.Peking Univ, Ctr Human Dis Genom, Beijing 100191, Peoples R China

Recommended Citation:
Hou, Rong,Ohtsuji, Mareki,Ohtsuji, Naomi,et al. Centromeric interval of chromosome 4 derived from C57BL/6 mice accelerates type 1 diabetes in NOD.CD72(b) congenic mice[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2009,380(1):193-197.
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