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Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappa B pathways
Zhang, Yi1; Foster, Robert1; Sun, Xiuli4; Yin, Qiaoqiao1; Li, Yi1; Hanley, Gregory3; Stuart, Charles1; Gan, Yili1; Li, Chuanfu2; Zhang, Zhiyong5; Yin, Deling1
关键词Restraint Stress Mice Lymphocyte Reduction P53 Pi3k Nf-kappa b
刊名JOURNAL OF NEUROIMMUNOLOGY
2008-08-30
DOI10.1016/j.jneuroim.2008.06.014
200期:1-2页:71-76
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Immunology ; Neurosciences
研究领域[WOS]Immunology ; Neurosciences & Neurology
关键词[WOS]NF-KAPPA-B ; FAS-MEDIATED APOPTOSIS ; IMMUNE-SYSTEM ; IN-VIVO ; PHOSPHOINOSITIDE 3-KINASE ; ACTIVATION ; EXPRESSION ; INVOLVEMENT ; INHIBITION ; MODULATION
英文摘要

Restraint stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced lymphocyte reduction remains to be elucidated. We have previously shown that chronic stress induces Fas-mediated lymphocyte reduction. Here, we investigated the mechanisms by which restraint stress modulates lymphocyte reduction. Our data have shown that inhibition of p53 by the p53 inhibitor PFT-alpha attenuates stress-induced reduction in lymphocyte numbers. These results were verified using p53 knockout mice, suggesting a pivotal role of p53 in this process. In addition our data have indicated that PI3K/nuclear factor kappa B (NF-kappa B) signaling pathway plays an important role in the stress-induced lymphocyte reduction. Our study thus demonstrates that restraint stress promotes lymphocyte reduction through p53 and PI3K/NF-kappa B pathways. (c) 2008 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000259951200008
项目编号DA020120 ; 0048 ; 07-26M
资助机构National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee (ETSU RDC)
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53483
专题北京大学第二临床医学院
作者单位1.E Tennessee State Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
2.E Tennessee State Univ, Coll Med, Dept Surg, Johnson City, TN 37614 USA
3.E Tennessee State Univ, Coll Med, Dept Lab Anim Resources, Johnson City, TN 37614 USA
4.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
5.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 200433, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Yi,Foster, Robert,Sun, Xiuli,et al. Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappa B pathways[J]. JOURNAL OF NEUROIMMUNOLOGY,2008,200(1-2):71-76.
APA Zhang, Yi.,Foster, Robert.,Sun, Xiuli.,Yin, Qiaoqiao.,Li, Yi.,...&Yin, Deling.(2008).Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappa B pathways.JOURNAL OF NEUROIMMUNOLOGY,200(1-2),71-76.
MLA Zhang, Yi,et al."Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappa B pathways".JOURNAL OF NEUROIMMUNOLOGY 200.1-2(2008):71-76.
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