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学科主题: 临床医学
题名:
Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappa B pathways
作者: Zhang, Yi1; Foster, Robert1; Sun, Xiuli4; Yin, Qiaoqiao1; Li, Yi1; Hanley, Gregory3; Stuart, Charles1; Gan, Yili1; Li, Chuanfu2; Zhang, Zhiyong5; Yin, Deling1
关键词: Restraint stress ; Mice ; Lymphocyte reduction ; p53 ; PI3K ; NF-kappa B
刊名: JOURNAL OF NEUROIMMUNOLOGY
发表日期: 2008-08-30
DOI: 10.1016/j.jneuroim.2008.06.014
卷: 200, 期:1-2, 页:71-76
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology ; Neurosciences
研究领域[WOS]: Immunology ; Neurosciences & Neurology
关键词[WOS]: NF-KAPPA-B ; FAS-MEDIATED APOPTOSIS ; IMMUNE-SYSTEM ; IN-VIVO ; PHOSPHOINOSITIDE 3-KINASE ; ACTIVATION ; EXPRESSION ; INVOLVEMENT ; INHIBITION ; MODULATION
英文摘要:

Restraint stress, either physical or psychological, can modulate immune function. However, the mechanisms associated with stress-induced lymphocyte reduction remains to be elucidated. We have previously shown that chronic stress induces Fas-mediated lymphocyte reduction. Here, we investigated the mechanisms by which restraint stress modulates lymphocyte reduction. Our data have shown that inhibition of p53 by the p53 inhibitor PFT-alpha attenuates stress-induced reduction in lymphocyte numbers. These results were verified using p53 knockout mice, suggesting a pivotal role of p53 in this process. In addition our data have indicated that PI3K/nuclear factor kappa B (NF-kappa B) signaling pathway plays an important role in the stress-induced lymphocyte reduction. Our study thus demonstrates that restraint stress promotes lymphocyte reduction through p53 and PI3K/NF-kappa B pathways. (c) 2008 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: DA020120 ; 0048 ; 07-26M
项目资助者: National Institutes of Health (NIH) ; East Tennessee State University Research Development Committee (ETSU RDC)
WOS记录号: WOS:000259951200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53483
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.E Tennessee State Univ, Coll Med, Dept Internal Med, Johnson City, TN 37614 USA
2.E Tennessee State Univ, Coll Med, Dept Surg, Johnson City, TN 37614 USA
3.E Tennessee State Univ, Coll Med, Dept Lab Anim Resources, Johnson City, TN 37614 USA
4.Peking Univ, Peoples Hosp, Dept Obstet & Gynecol, Beijing 100871, Peoples R China
5.Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai 200433, Peoples R China

Recommended Citation:
Zhang, Yi,Foster, Robert,Sun, Xiuli,et al. Restraint stress induces lymphocyte reduction through p53 and PI3K/NF-kappa B pathways[J]. JOURNAL OF NEUROIMMUNOLOGY,2008,200(1-2):71-76.
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