北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 内分泌内科  > 期刊论文
学科主题: 临床医学
题名:
Postprandial blood glucose response to a standard test meal in insulin-requiring patients with diabetes treated with insulin lispro mix 50 or human insulin mix 50
作者: Gao, Y.1; Li, G.2; Li, Y.3; Guo, X.1; Yuan, G.1; Gong, Q.2; Yan, L.3; Zheng, Y.; Zhang, J.4
刊名: INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
发表日期: 2008-09-01
DOI: 10.1111/j.1742-1241.2008.01850.x
卷: 62, 期:9, 页:1344-1351
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]: General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]: GLYCEMIC CONTROL ; HYPERGLYCEMIA ; CROSSOVER ; MIXTURES ; MELLITUS ; TYPE-1 ; TRIAL ; MIX25 ; RISK
英文摘要:

Aim: To compare the 2-h postprandial blood glucose (PPBG) excursion following a standard test meal in insulin-requiring patients with diabetes treated twice daily with human insulin mix 50 vs. insulin lispro mix 50 (LM50). Methods: This was a multicentre, randomised, open-label, crossover comparison of two insulin treatments for two 12-week treatment periods in 120 Chinese patients. One- and 2-h PPBG and excursion values were obtained following a standardised test meal. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), insulin dose, rate of hypoglycaemia and safety data were obtained. A crossover analysis using SAS Proc MIXED was employed. Results: Mean 2-h PPBG excursion decreased from 6.32 +/- 3.07 mmol/l at baseline to 3.47 +/- 2.97 mmol/l at end-point in the LM50 group, and from 6.31 +/- 2.88 at baseline to 5.02 +/- 3.32 mmol/l at end-point in the human insulin mix 50 group (p < 0.001). Two-hour PPBG (p = 0.004) and 1-h PPBG excursion (p < 0.001) were significantly lower with LM50 as compared with human insulin mix 50. Both treatment groups were equivalent for HbA1c control, 1-h PPBG and insulin dose requirements. Mean FBG was higher with LM50 than with human insulin mix 50 (p = 0.023). The overall incidence of treatment-emergent adverse events and hypoglycaemia rate per 30 days were similar between treatment groups. Conclusions: Insulin lispro mix 50 provided better postprandial glycaemic control compared with human insulin mix 50 while providing the convenience of injecting immediately before meals. Both treatments were generally well tolerated by all randomly assigned patients.

语种: 英语
WOS记录号: WOS:000258291100010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53489
Appears in Collections:北京大学第一临床医学院_内分泌内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Sino Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
4.Eli Lilly Asia Inc, Shanghai Rap Off 21F, Shanghai 200021, Peoples R China

Recommended Citation:
Gao, Y.,Li, G.,Li, Y.,et al. Postprandial blood glucose response to a standard test meal in insulin-requiring patients with diabetes treated with insulin lispro mix 50 or human insulin mix 50[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2008,62(9):1344-1351.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Y.]'s Articles
[Li, G.]'s Articles
[Li, Y.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Y.]‘s Articles
[Li, G.]‘s Articles
[Li, Y.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace