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学科主题临床医学
Postprandial blood glucose response to a standard test meal in insulin-requiring patients with diabetes treated with insulin lispro mix 50 or human insulin mix 50
Gao, Y.1; Li, G.2; Li, Y.3; Guo, X.1; Yuan, G.1; Gong, Q.2; Yan, L.3; Zheng, Y.; Zhang, J.4
刊名INTERNATIONAL JOURNAL OF CLINICAL PRACTICE
2008-09-01
DOI10.1111/j.1742-1241.2008.01850.x
62期:9页:1344-1351
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal ; Pharmacology & Pharmacy
研究领域[WOS]General & Internal Medicine ; Pharmacology & Pharmacy
关键词[WOS]GLYCEMIC CONTROL ; HYPERGLYCEMIA ; CROSSOVER ; MIXTURES ; MELLITUS ; TYPE-1 ; TRIAL ; MIX25 ; RISK
英文摘要

Aim: To compare the 2-h postprandial blood glucose (PPBG) excursion following a standard test meal in insulin-requiring patients with diabetes treated twice daily with human insulin mix 50 vs. insulin lispro mix 50 (LM50). Methods: This was a multicentre, randomised, open-label, crossover comparison of two insulin treatments for two 12-week treatment periods in 120 Chinese patients. One- and 2-h PPBG and excursion values were obtained following a standardised test meal. Fasting blood glucose (FBG), haemoglobin A1c (HbA1c), insulin dose, rate of hypoglycaemia and safety data were obtained. A crossover analysis using SAS Proc MIXED was employed. Results: Mean 2-h PPBG excursion decreased from 6.32 +/- 3.07 mmol/l at baseline to 3.47 +/- 2.97 mmol/l at end-point in the LM50 group, and from 6.31 +/- 2.88 at baseline to 5.02 +/- 3.32 mmol/l at end-point in the human insulin mix 50 group (p < 0.001). Two-hour PPBG (p = 0.004) and 1-h PPBG excursion (p < 0.001) were significantly lower with LM50 as compared with human insulin mix 50. Both treatment groups were equivalent for HbA1c control, 1-h PPBG and insulin dose requirements. Mean FBG was higher with LM50 than with human insulin mix 50 (p = 0.023). The overall incidence of treatment-emergent adverse events and hypoglycaemia rate per 30 days were similar between treatment groups. Conclusions: Insulin lispro mix 50 provided better postprandial glycaemic control compared with human insulin mix 50 while providing the convenience of injecting immediately before meals. Both treatments were generally well tolerated by all randomly assigned patients.

语种英语
WOS记录号WOS:000258291100010
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53489
专题北京大学第一临床医学院_内分泌内科
作者单位1.Sino Japan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
3.Sun Yat Sen Univ, Affiliated Hosp 2, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
4.Eli Lilly Asia Inc, Shanghai Rap Off 21F, Shanghai 200021, Peoples R China
推荐引用方式
GB/T 7714
Gao, Y.,Li, G.,Li, Y.,et al. Postprandial blood glucose response to a standard test meal in insulin-requiring patients with diabetes treated with insulin lispro mix 50 or human insulin mix 50[J]. INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,2008,62(9):1344-1351.
APA Gao, Y..,Li, G..,Li, Y..,Guo, X..,Yuan, G..,...&Zhang, J..(2008).Postprandial blood glucose response to a standard test meal in insulin-requiring patients with diabetes treated with insulin lispro mix 50 or human insulin mix 50.INTERNATIONAL JOURNAL OF CLINICAL PRACTICE,62(9),1344-1351.
MLA Gao, Y.,et al."Postprandial blood glucose response to a standard test meal in insulin-requiring patients with diabetes treated with insulin lispro mix 50 or human insulin mix 50".INTERNATIONAL JOURNAL OF CLINICAL PRACTICE 62.9(2008):1344-1351.
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