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学科主题: 精神卫生
题名:
The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia and the follow-up study
作者: Quan, Wen Xiang1,2; Zhu, Xiao Lin3; Qiao, Hong1,2; Zhang, Wu Fang1,2; Tan, Shu Ping3; Zhou, Dong Feng1,2; Wang, Xiang Qun1,2
关键词: Repetitive transcranial magnetic stimulation ; Schizophrenia ; Negative symptoms
刊名: NEUROSCIENCE LETTERS
发表日期: 2015
DOI: 10.1016/j.neulet.2014.10.029
卷: 584, 页:197-201
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DOUBLE-BLIND ; RAT-BRAIN ; RELEASE ; HYPOFRONTALITY ; INCREASES ; DOPAMINE ; CORTEX ; PANSS
英文摘要:

In this double-blind, randomized controlled study, we assessed the therapeutic effects of high-frequency left dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia. For the study, 117 patients with prominent negative symptoms were randomized to a 20-day course of either active rTMS applied to the left DLPFC (n = 78) or sham rTMS (n = 39). The primary outcome measures were the Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Secondary outcomes included the Clinical Global Impressions Scale (CGI) and the Udvalg for Kliniske Under sogelser (UKU) Side Effect Rating Scale. We found that treatment with high-frequency rTMS for 6weeks significantly improved negative symptoms in the active group as compared to the sham group. However, active rTMS was not correlated with significant improvement in the CGI severity of illness scale (CGI-S). The improvement of negative symptoms persisted to the 24-week follow-up assessment. These results indicate that there is a lasting beneficial effect of rTMS on negative symptoms in absence of decrease in CGI scores. We conclude that rTMS may serve as a relatively noninvasive treatment that alleviates negative symptoms in patients with schizophrenia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
所属项目编号: 0906001040291
项目资助者: Beijing Municipal Science &amp ; Technology Commission
WOS记录号: WOS:000347579000038
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53490
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China

Recommended Citation:
Quan, Wen Xiang,Zhu, Xiao Lin,Qiao, Hong,et al. The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia and the follow-up study[J]. NEUROSCIENCE LETTERS,2015,584:197-201.
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