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The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia and the follow-up study
Quan, Wen Xiang1,2; Zhu, Xiao Lin3; Qiao, Hong1,2; Zhang, Wu Fang1,2; Tan, Shu Ping3; Zhou, Dong Feng1,2; Wang, Xiang Qun1,2
关键词Repetitive Transcranial Magnetic Stimulation Schizophrenia Negative Symptoms
刊名NEUROSCIENCE LETTERS
2015
DOI10.1016/j.neulet.2014.10.029
584页:197-201
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DOUBLE-BLIND ; RAT-BRAIN ; RELEASE ; HYPOFRONTALITY ; INCREASES ; DOPAMINE ; CORTEX ; PANSS
英文摘要

In this double-blind, randomized controlled study, we assessed the therapeutic effects of high-frequency left dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia. For the study, 117 patients with prominent negative symptoms were randomized to a 20-day course of either active rTMS applied to the left DLPFC (n = 78) or sham rTMS (n = 39). The primary outcome measures were the Positive and Negative Symptom Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Secondary outcomes included the Clinical Global Impressions Scale (CGI) and the Udvalg for Kliniske Under sogelser (UKU) Side Effect Rating Scale. We found that treatment with high-frequency rTMS for 6weeks significantly improved negative symptoms in the active group as compared to the sham group. However, active rTMS was not correlated with significant improvement in the CGI severity of illness scale (CGI-S). The improvement of negative symptoms persisted to the 24-week follow-up assessment. These results indicate that there is a lasting beneficial effect of rTMS on negative symptoms in absence of decrease in CGI scores. We conclude that rTMS may serve as a relatively noninvasive treatment that alleviates negative symptoms in patients with schizophrenia. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000347579000038
项目编号0906001040291
资助机构Beijing Municipal Science &amp ; Technology Commission
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53490
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 6, Inst Mental Hlth, Key Lab Mental Hlth,Minist Hlth, Beijing 100191, Peoples R China
3.Beijing Huilongguan Hosp, Ctr Psychiat Res, Beijing 100096, Peoples R China
推荐引用方式
GB/T 7714
Quan, Wen Xiang,Zhu, Xiao Lin,Qiao, Hong,et al. The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia and the follow-up study[J]. NEUROSCIENCE LETTERS,2015,584:197-201.
APA Quan, Wen Xiang.,Zhu, Xiao Lin.,Qiao, Hong.,Zhang, Wu Fang.,Tan, Shu Ping.,...&Wang, Xiang Qun.(2015).The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia and the follow-up study.NEUROSCIENCE LETTERS,584,197-201.
MLA Quan, Wen Xiang,et al."The effects of high-frequency repetitive transcranial magnetic stimulation (rTMS) on negative symptoms of schizophrenia and the follow-up study".NEUROSCIENCE LETTERS 584(2015):197-201.
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