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学科主题基础医学
Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice
Li, A.; Zhang, Q.; Jiang, J.; Yuan, G.; Feng, Y.; Hao, J.; Li, C.; Gao, X.; Wang, G.; Xie, S.
关键词allogeneic bone marrow transplantation adenovirus vectors interleukin-7 immune reconstitution graft-versus-host disease
刊名GENE THERAPY
2006-08-01
DOI10.1038/sj.gt.3302741
13期:15页:1178-1187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity ; Medicine, Research & Experimental
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Genetics & Heredity ; Research & Experimental Medicine
关键词[WOS]MESENCHYMAL STEM-CELLS ; RECENT THYMIC EMIGRANTS ; VERSUS-HOST-DISEASE ; DEFICIENT MICE ; INTERLEUKIN-7 ; DONOR ; EXPANSION ; DIFFERENTIATION ; THYMOPOIESIS ; LYMPHOCYTES
英文摘要

Allogeneic bone marrow transplantation (allo-BMT) is followed by a period of profound immune deficiency, which results in significant susceptibility to infections and limits the extensive application of this approach in clinic. Here, we transduced human interleukin-7 (IL-7) gene into donor-derived bone marrow stromal cells (MSCs) using adenovirus vector, and transplanted this gene-engineered MSCs (MSC-IL-7) into lethally irradiated C57BL/ 6 mice to investigate their effects on immune reconstitution following allo-BMT. Recipient mice receiving MSC-IL-7 cells plus T-cell-depleted bone marrow cells of BALB/ c mice showed a significant increase in thymopoiesis and homeostatic expansion of peripheral T lymphocytes. Furthermore, injection of MSC-IL-7 cells following allo-BMT protected the host from the lethality caused by acute graft-versus-host disease (GVHD) and prevented the occurrence of GVHD induced by transplanted T cells. Thus, the use of MSC-IL-7 cells may be therapeutically useful for enhancing immune reconstitution without aggravating GVHD in allo-BMT mice.

语种英语
WOS记录号WOS:000239084800007
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被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53493
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Ctr Hlth, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Li, A.,Zhang, Q.,Jiang, J.,et al. Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice[J]. GENE THERAPY,2006,13(15):1178-1187.
APA Li, A..,Zhang, Q..,Jiang, J..,Yuan, G..,Feng, Y..,...&Xie, S..(2006).Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice.GENE THERAPY,13(15),1178-1187.
MLA Li, A.,et al."Co-transplantation of bone marrow stromal cells transduced with IL-7 gene enhances immune reconstitution after allogeneic bone marrow transplantation in mice".GENE THERAPY 13.15(2006):1178-1187.
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