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学科主题临床医学
Continued Decline of Aqueous Interleukin-8 After Multiple Intravitreal Injections of Ganciclovir for Cytomegalovirus Retinitis
Wang, Bin1,2; Tian, Bei3; Tao, Yong1,2; Hou, Jing1,2; Zhao, Xiao-Tao4; Li, Xiao-Xin1,2
刊名JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS
2014-09-01
DOI10.1089/jop.2013.0241
30期:7页:587-592
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Ophthalmology ; Pharmacology & Pharmacy
研究领域[WOS]Ophthalmology ; Pharmacology & Pharmacy
关键词[WOS]RETROVIRUS-INDUCED IMMUNODEFICIENCY ; ACUTE LYMPHOBLASTIC-LEUKEMIA ; MAINTENANCE THERAPY ; INTRAOCULAR LEVELS ; MESSENGER-RNA ; IMMUNOTHERAPY ; MAIDS ; MICE ; DISEASE ; CANCER
英文摘要

Purpose: To evaluate the relationship between aqueous inflammation cytokines and cytomegalovirus (CMV) particles in patients with cytomegalovirus retinitis (CMVR), and evaluate the changes in aqueous inflammation cytokines during multiple intravitreal injections of antiviral drugs for CMVR.

Methods: There were 10 patients (12 eyes; 16 courses of treatment per eye) who underwent continued intravitreal ganciclovir or foscarnet for treatment of CMVR. Before each intravitreal injection, 50-100 mu L of aqueous humor was removed and sent to the laboratory to examine the concentration of the CMV DNA load by using polymerase chain reaction and to examine the concentration of interleukin (IL)-1 beta, IL-6, IL-8, IL-10, tumor necrosis factor (TNF)-alpha, and IL-12p70 using a cytometric bead array.

Results: A Kendall correlation test showed that the concentration of the CMV DNA load in the aqueous humor was significantly associated with the aqueous level of IL-6 (P < 0.001, r = 0.327) and IL-8 (P < 0.001, r = 0.381), but not significantly associated with IL-1 beta, IL-10, IL-12p70, and TNF-alpha. The boxplots showed that the concentration of the aqueous CMV DNA load, IL-8 and IL-10 continuously declined after multiple intravitreal injections of antiviral drugs, and the decline trend of IL-8 was most remarkable. IL-1 beta, IL-10, TNF-alpha, and IL-12p70 were negative in some of the aqueous levels of CMVR patients throughout the course of treatment (25.0%-62.5%).

Conclusions: Our study showed that IL-8 was significantly associated with the aqueous level of CMV copies and continuously declined during a course of treatment that involved multiple intravitreal injections of antiviral drugs. IL-8 may be considered a good quantitative laboratory indicator of the recovery of CMVR.

语种英语
WOS记录号WOS:000341737200011
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53496
专题北京大学第二临床医学院_眼科
北京大学第二临床医学院_检验科
作者单位1.Peking Univ, Peoples Hosp, Dept Ophthalmol, Beijing 100044, Peoples R China
2.Minist Educ, Beijing Key Lab Diag & Therapy Retinal & Choroid, Key Lab Vis Loss & Restorat, Beijing, Peoples R China
3.Capital Med Univ, Beijing Tongren Hosp, Beijing Tongren Eye Ctr, Beijing Ophthalmol & Visual Sci Key Lab, Beijing, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100871, Peoples R China
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GB/T 7714
Wang, Bin,Tian, Bei,Tao, Yong,et al. Continued Decline of Aqueous Interleukin-8 After Multiple Intravitreal Injections of Ganciclovir for Cytomegalovirus Retinitis[J]. JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,2014,30(7):587-592.
APA Wang, Bin,Tian, Bei,Tao, Yong,Hou, Jing,Zhao, Xiao-Tao,&Li, Xiao-Xin.(2014).Continued Decline of Aqueous Interleukin-8 After Multiple Intravitreal Injections of Ganciclovir for Cytomegalovirus Retinitis.JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS,30(7),587-592.
MLA Wang, Bin,et al."Continued Decline of Aqueous Interleukin-8 After Multiple Intravitreal Injections of Ganciclovir for Cytomegalovirus Retinitis".JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS 30.7(2014):587-592.
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