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学科主题基础医学
Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis
Dai, Hui2; Gao, Xiao-Ming1
关键词autoantibody anti-alpha-1 6-glucan autoimmune diseases systemic lupus erythematosus rheumatoid arthritis
刊名PROTEIN & CELL
2011-09-01
DOI10.1007/s13238-011-1095-1
2期:9页:739-744
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology
研究领域[WOS]Cell Biology
关键词[WOS]SACCHAROMYCES-CEREVISIAE MANNAN ; SULFATE CELLULOSE COLUMNS ; ANTI-DNA ; CROSS-REACTIVITY ; REVISED CRITERIA ; GAL EPITOPE ; DISEASE ; XENOTRANSPLANTATION ; CLASSIFICATION ; SELESORB
英文摘要

This study was undertaken to investigate whether levels of anti-alpha-1, 6-glucan antibodies in human sera correlate with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Serum samples were collected from patients with SLE (n = 30), RA (n = 30) and healthy adult volunteers. IgG, IgA and IgM levels against alpha-1, 6-glucan were measured using enzyme linked immunosorbent assays. Anti-alpha-1, 6-glucan IgG prevalence was raised in patients with active SLE (73.3%) and RA (60%) compared with healthy controls (13.3%). Strong correlation between anti-alpha-1,6-glucan-IgG levels and anti-perinuclear factor (r = 0.642; p < 0.05) in RA patients or anti-nuclear antibodies (r = 0.675; p < 0.05) in SLE patients was observed. No significant differences in anti-alpha-1,6-glucan-IgA or-IgM levels were noted between different groups. We conclude that anti-alpha-1,6-glucan-IgG levels were significantly elevated in patients with SLE or RA and positively correlated with disease activity.

语种英语
WOS记录号WOS:000310522000008
项目编号2007CB512406 ; 2006AA02Z495 ; 30371303
资助机构National Key Basic Research Program ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53498
专题北京大学基础医学院_免疫学系
作者单位1.Soochow Univ, Inst Biol & Med Sci, Suzhou 215123, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
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Dai, Hui,Gao, Xiao-Ming. Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis[J]. PROTEIN & CELL,2011,2(9):739-744.
APA Dai, Hui,&Gao, Xiao-Ming.(2011).Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis.PROTEIN & CELL,2(9),739-744.
MLA Dai, Hui,et al."Elevated levels of serum antibodies against alpha-1, 6-glucan in patients with systemic lupus erythematosus or rheumatoid arthritis".PROTEIN & CELL 2.9(2011):739-744.
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