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学科主题临床医学
CDH1 germline mutation in hereditary gastric carcinoma
Wang, Hai-Dan2,3; Ren, Jun1; Zhang, Lian
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2004-11-01
10期:21页:3088-3093
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
英文摘要

This paper provides a bird′s-eye view both in preclinical and clinical aspects of E-cadherin germline gene (CDH1) in gastric cancer patients and their families. E-cadherin, a product of CDH1 gene, belonging to the functionally related trans-membrane glycoprotein family, is responsible for the Ca(2+)-dependent cell-cell adhesion mechanism and contributes to dissociation followed by acquisition of cell motility, which usually occurs in the first step of cancer invasion and metastasis. CDH1 gene germline mutation is common in many types of carcinoma, and occurs very frequent in hereditary gastric carcinoma (HGC) patients and their families. Recently, more and more researches support that E-cadherin plays an important role in the differentiation, growth and invasion of HGC. So it is of great value to clarify its mechanisms both for understanding HGC pathogenesis and for clinical therapy, especially in China, where there are a high risk population of gastric cancer and a high HGC incidence rate. In this paper, recent researches on CDH1 gene mutation, especially its role in tumor genesis and progress of HGC, are reviewed, and advances in evaluation of its mutation status for HGC diagnosis, therapy and prognosis, are also discussed briefly.

语种英语
WOS记录号WOS:000208098200002
项目编号TRAPOYT99-016
资助机构Ministry of Education, P R China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53507
专题北京大学临床肿瘤学院_肿瘤内科
作者单位1.Peking Univ, Sch Oncol, Dept Med Oncol, Beijing 100036, Peoples R China
2.Fourth Mil Med Univ, Xijing Hosp, Ctr Clin Oncol, Xian 710032, Shaanxi Provinc, Peoples R China
3.Fourth Mil Med Univ, Xijing Hosp, Int Collaborat Grp Hereditary Gastr Carcinoma, Xian 710032, Shaanxi Provinc, Peoples R China
推荐引用方式
GB/T 7714
Wang, Hai-Dan,Ren, Jun,Zhang, Lian. CDH1 germline mutation in hereditary gastric carcinoma[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2004,10(21):3088-3093.
APA Wang, Hai-Dan,Ren, Jun,&Zhang, Lian.(2004).CDH1 germline mutation in hereditary gastric carcinoma.WORLD JOURNAL OF GASTROENTEROLOGY,10(21),3088-3093.
MLA Wang, Hai-Dan,et al."CDH1 germline mutation in hereditary gastric carcinoma".WORLD JOURNAL OF GASTROENTEROLOGY 10.21(2004):3088-3093.
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