|Detection of mild to moderate influenza A/H7N9 infection by China′s national sentinel surveillance system for influenza-like illness: case series|
|Dennis, K. M.1; Liao, Qiaohong2; Wu, Peng1; Gao, Zhancheng3; Cao, Bin4; Feng, Luzhao2; Xu, Xiaoling5; Jiang, Hui2; Li, Ming2; Bao, Jing3; Zheng, Jiandong2; Zhang, Qian2; Chang, Zhaorui2; Li, Yu2; Yu, Jianxing2; Liu, Fengfeng2; Ni, Michael Y.1; Wu, Joseph T.1; Cowling, Benjamin J.1; Yang, Weizhong6; Leung, Gabriel M.1; Yu, Hongjie2|
|刊名||BMJ-BRITISH MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||VIRUS ; POULTRY ; DISEASE|
Objective To characterise the complete case series of influenza A/H7N9 infections as of 27 May 2013, detected by China′s national sentinel surveillance system for influenza-like illness.
Design Case series.
Setting Outpatient clinics and emergency departments of 554 sentinel hospitals across 31 provinces in mainland China.
Cases Infected individuals were identified through cross-referencing people who had laboratory confirmed A/H7N9 infection with people detected by the sentinel surveillance system for influenza-like illness, where patients meeting the World Health Organization′s definition of influenza-like illness undergo weekly surveillance, and 10-15 nasopharyngeal swabs are collected each week from a subset of patients with influenza-like illness in each hospital for virological testing. We extracted relevant epidemiological data from public health investigations by the Centers for Disease Control and Prevention at the local, provincial, and national level; and clinical and laboratory data from chart review.
Main outcome measure Epidemiological, clinical, and laboratory profiles of the case series.
Results Of 130 people with laboratory confirmed A/H7N9 infection as of 27 May 2013, five (4%) were detected through the sentinel surveillance system for influenza-like illness. Mean age was 13 years (range 2-26), and none had any underlying medical conditions. Exposure history, geographical location, and timing of symptom onset of these five patients were otherwise similar to the general cohort of laboratory confirmed cases so far. Only two of the five patients needed hospitalisation, and all five had mild or moderate disease with an uneventful course of recovery.
Conclusion Our findings support the existence of a "clinical iceberg" phenomenon in influenza A/H7N9 infections, and reinforce the need for vigilance to the diverse presentation that can be associated with A/H7N9 infection. At the public health level, indirect evidence suggests a substantial proportion of mild disease in A/H7N9 infections.
|项目编号||U19 AI51915 ; 2012 ZX10004-201 ; U54 GM088558 ; AoE/M-12/06|
|资助机构||US National Institutes of Health (Comprehensive International Program for Research on AIDS) ; China-US collaborative program on emerging and re-emerging infectious diseases ; Chinese Ministry of Science and Technology ; Harvard Center for Communicable Disease Dynamics from the National Institute of General Medical Sciences ; Research Fund for the Control of Infectious Disease, Food, and Health Bureau (government of the Hong Kong Special Administrative Region) ; Hong Kong University|
|作者单位||1.Anhui Prov Hosp, Dept Resp Med, Hefei, Peoples R China|
2.Univ Hong Kong, Li Ka Shing Fac Med, Sch Publ Hlth, Infect Dis Epidemiol Grp, Hong Kong, Hong Kong, Peoples R China
3.Chinese Ctr Dis Control & Prevent, Div Infect Dis, Key Lab Surveillance & Early Warning Infect Dis, Beijing 102206, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Resp & Crit Care Med, Beijing 100871, Peoples R China
5.Capital Med Univ, Beijing Inst Resp Med, Beijing Chao Yang Hosp, Dept Infect Dis & Clin Microbiol, Beijing, Peoples R China
6.Chinese Ctr Dis Control & Prevent, Off Director, Beijing, Peoples R China
|Dennis, K. M.,Liao, Qiaohong,Wu, Peng,et al. Detection of mild to moderate influenza A/H7N9 infection by China′s national sentinel surveillance system for influenza-like illness: case series[J]. BMJ-BRITISH MEDICAL JOURNAL,2013,346.|
|APA||Dennis, K. M..,Liao, Qiaohong.,Wu, Peng.,Gao, Zhancheng.,Cao, Bin.,...&Yu, Hongjie.(2013).Detection of mild to moderate influenza A/H7N9 infection by China′s national sentinel surveillance system for influenza-like illness: case series.BMJ-BRITISH MEDICAL JOURNAL,346.|
|MLA||Dennis, K. M.,et al."Detection of mild to moderate influenza A/H7N9 infection by China′s national sentinel surveillance system for influenza-like illness: case series".BMJ-BRITISH MEDICAL JOURNAL 346(2013).|
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