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学科主题: 临床医学
题名:
Determining leaf trajectories for dynamic multileaf collimators with consideration of marker visibility: an algorithm study
作者: Zhao, Bo1,2,3; Dai, Jianrong1,2
关键词: algorithm ; DMLC-IMRT ; sliding window ; leaf trajectory ; marker visibility
刊名: JOURNAL OF RADIATION RESEARCH
发表日期: 2014-09-01
DOI: 10.1093/jrr/rru035
卷: 55, 期:5, 页:976-987
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biology ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Life Sciences & Biomedicine - Other Topics ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MODULATED RADIATION-THERAPY ; TUMOR MOTION ; GATED RADIOTHERAPY ; MOVING TARGETS ; IMRT DELIVERY ; MLC TRACKING ; TIME ; KV ; POSITION ; FIELDS
英文摘要:

The purpose of this study was to develop a leaf-setting algorithm for Dynamic Multileaf Collimator-Intensity-Modulated Radiation Therapy (DMLC-IMRT) for optimal marker visibility. Here, a leaf-setting algorithm (called a Delta algorithm) was developed with the objective of maximizing marker visibility so as to improve the tracking effectiveness of fiducial markers during treatment delivery. The initial leaf trajectories were generated using a typical leaf-setting algorithm, then the leaf trajectories were adjusted by Delta algorithm operations (analytical computations and a series of matrix calculations) to achieve the optimal solution. The performance of the Delta algorithm was evaluated with six test fields (with randomly generated intensity profiles) and 15 clinical fields from IMRT plans of three prostate cancer patients. Compared with the initial solution, the Delta algorithm kept the total delivered intensities (TDIs) constant (without increasing the beam delivery time), but improved marker visibility (the percentage ratio of marker visibility time to beam delivery time). For the artificial fields (with three markers), marker visibility increased from 68.00-72.00% for a small field (5 x 5), from 38.46-43.59% for a medium field (10 x 10), and from 28.57-37.14% for a large field (20 x 20). For the 15 clinical fields, marker visibility increased 6-30% for eight fields and > 50% for two fields but did not change for five fields. A Delta algorithm was proposed to maximize marker visibility for DMLC-IMRT without increasing beam delivery time, and this will provide theoretical fundamentals for future studies of 4D DMLC tracking radiotherapy.

语种: 英语
所属项目编号: 10975187
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000342223100017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53515
Appears in Collections:北京大学第一临床医学院_肿瘤化疗科_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Canc Inst Hosp, Dept Radiat Oncol, Beijing 100021, Peoples R China
2.Peking Union Med Coll, Beijing 100021, Peoples R China
3.Peking Univ, Dept Radiat Oncol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Zhao, Bo,Dai, Jianrong. Determining leaf trajectories for dynamic multileaf collimators with consideration of marker visibility: an algorithm study[J]. JOURNAL OF RADIATION RESEARCH,2014,55(5):976-987.
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