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学科主题: 临床医学
题名:
The Clinical and Histological Characteristics and Outcomes of Drug Induced Chronic Liver Injury After Removing Causative Drugs
作者: Hou, Feng-Qin1,2; Wang, Tai-Ling3; Liu, Xia3; Huo, Na1,2; Wang, Gui-Qiang1,2
关键词: Drugs ; Chronic liver injury
刊名: HEPATO-GASTROENTEROLOGY
发表日期: 2010-05-01
卷: 57, 期:99-100, 页:554-561
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology ; Surgery
研究领域[WOS]: Gastroenterology & Hepatology ; Surgery
关键词[WOS]: TERM-FOLLOW-UP ; UNITED-STATES ; DISORDERS ; FAILURE ; DISEASE
英文摘要:

Background/Aims: To investigate characteristics and outcomes of drug induced chronic liver injury after removing causative drugs.

Methodology: Between Apr 2001 and Mar 2010, patients diagnosed as drug induced liver injury and with chronic courses, were observed. Chronic liver injury was defined as persistent biochemical abnormality for more than 6 months after drugs withdrawal.

Results: Forty patients were observed with mean age 41 years and female 28 (70%). Of the 40 patients, 32 (80%) cases showed hepatocellular injury at the onset of liver damage, 4 (10%) cases showed cholestatic injury, and 4 (10%) cases showed mixed injury. Of 32 patients with hepatocellular injury, 24(75%) cases resemble acute icteric hepatitis at the onset of liver damage. Of 27 patients with hepatocellular injury who underwent liver biopsy, 14 (51.9%) cases showed chronic hepatitis with a mean follow up of 17 months. Of total 40 patients, 15 (37.5%) patients resolved; 18 (45%) cases remained persistent liver injury, 4 (10%) cases developed cirrhosis, 3 (7.5%) cases died. Herbs (45.5%) are the commonest drugs implicated in chronic liver injury.

Conclusions: Most cases with drug induced chronic liver injury after removing causative drugs resemble acute icteric hepatitis at the onset of liver damage. Some patients can resolve, some may progress to cirrhosis. Herbs are important drugs for drug induced chronic liver injury.

语种: 英语
WOS记录号: WOS:000280557900032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53517
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Peking Univ, Dept Infect Dis, Hosp 1, Beijing 100034, Peoples R China
2.Peking Univ, Ctr Liver Dis, Hosp 1, Beijing 100034, Peoples R China
3.China Japan Friendship Hosp, Dept Pathol, Beijing 100029, Peoples R China

Recommended Citation:
Hou, Feng-Qin,Wang, Tai-Ling,Liu, Xia,et al. The Clinical and Histological Characteristics and Outcomes of Drug Induced Chronic Liver Injury After Removing Causative Drugs[J]. HEPATO-GASTROENTEROLOGY,2010,57(99-100):554-561.
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