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学科主题: 临床医学
题名:
Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM STUDY
作者: Park, Soo-Heon; Cho, Chul-Soo; Lee, Oh-Young; Jun, Jae-Bum; Lin, San-Ren; Zhou, Li-Ya; Yuan, Yao-Zong; Li, Zhao-Shen; Hou, Xiao-Hua; Zhao, Hong-Chuan; Kachintorn, Udom; Kositchaiwat, Chomsri; Lertkupinit, Comson
关键词: rebamipide ; misoprostol ; NSAID ; gastrointestinal tract ; clinical trial
刊名: JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
发表日期: 2007
卷: 40, 期:2, 页:148-155
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: NONSTEROIDAL ANTIINFLAMMATORY DRUGS ; PLACEBO-CONTROLLED TRIAL ; GASTRIC-ULCER ; DOUBLE-BLIND ; RATS ; OMEPRAZOLE
英文摘要:

Nonsteroidal anti-inflammatory drugs (NSAIDs) have gastrointestinal side effects such as dyspepsia, peptic ulcer, hemorrhage, and perforation. Misoprostol and PPIs have been used to prevent NSAID-induced gastroduodenal injury. Rebamipide increases gastric mucus and stimulates the production of endogenous prostaglandins. The prophylactic effect of rebamipide on NSAID-induced gastrointestinal complications is unknown. The aim of this study was to compare NSAID-induced gastrointestinal complications in rebamipide- and misoprostol-treated groups. Patients were randomized to two groups and took a conventional NSAID plus rebamipide or misoprostol for 12 weeks. Gastric mucosal damage was evaluated by endoscopy at screening and the end of the study. The prevalences of active gastric ulcer were 7/176 (3.9%) in the rebamipide group and 3/156 (1.9%) in the misoprostol group. The prevalences of peptic ulcer were 8/176 (4.56/o) in the rebamipide group and 7/156 (4.4%) in the misoprostol group. The cumulative incidences of peptic ulcer in the high-risk subgroup were 6/151 (4.0%) for rebamipide and 6/154 (3.9%) for misoprostol. In conclusion, rebamipide prevented NSAID-induced peptic ulcer as effectively as misoprostol in patients on long-term NSAID therapy. Rebamipide may be a useful therapeutic option for the prevention of NSAID-induced gastrointestinal ulcer because of its therapeutic effect and safety.

语种: 英语
WOS记录号: WOS:000246232400011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/53522
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Chonburi Hosp, Chon Buri 20000, Thailand
2.Hanyang Univ Hosp, Seoul 133792, South Korea
3.Peking Univ, Hosp 3, Beijing 100083, Peoples R China
4.Beijing China Japan Friendship Hosp, Beijing 100029, Peoples R China
5.Mahidol Univ, Siriraj Hosp, Bangkok 10700, Thailand
6.Mahidol Univ, Ramathibodi Hosp, Bangkok 10400, Thailand
7.Catholic Univ Korea, St Marys Hosp, Seoul 150713, South Korea
8.Second Mil Med Univ, Changhai Hosp, Shanghai 200025, Peoples R China
9.Second Mil Med Univ, Changhai Hosp, Shanghai 2000433, Peoples R China
10.Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Wuhan 430022, Peoples R China

Recommended Citation:
Park, Soo-Heon,Cho, Chul-Soo,Lee, Oh-Young,et al. Comparison of prevention of NSAID-induced gastrointestinal complications by rebamipide and misoprostol: A randomized, multicenter, controlled trial - STORM STUDY[J]. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION,2007,40(2):148-155.
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