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Haploidentical SCT: the mechanisms underlying the crossing of HLA barriers
Chang, Y-J1,2; Huang, X-J1,2,3
关键词Haploidentical Transplantation Mechanism Immune Tolerance Human Leukocyte Antigen Barrier
刊名BONE MARROW TRANSPLANTATION
2014-07-01
DOI10.1038/bmt.2014.19
49期:7页:873-879
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; STEM-CELL TRANSPLANTATION ; REGULATORY T-CELLS ; COLONY-STIMULATING FACTOR ; VERSUS-HOST-DISEASE ; RISK HEMATOLOGIC MALIGNANCIES ; ACQUIRED APLASTIC-ANEMIA ; IN-VITRO ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; PERIPHERAL-BLOOD
英文摘要

Research on the different mechanisms for crossing HLA barriers has progressed over the past 10 years. General outlines have come into view for a solution to this issue and are often presented as ′haploidentical SCT′ immunology. In this review, we discuss several mechanisms that have recently been described in ex vivo and in vivo settings that can either avoid GVHD or promote hematopoietic reconstitution in haploidentical settings. The host and donor T-cell responses to allogeneic HLA molecules are a fundamental obstacle to the successful application of haploidentical transplantation, which results in unacceptably high incidences of GVHD and graft rejection. Thus, the T-cell response is a central factor in the establishment of a novel haploidentical transplant protocol with superior outcomes.

语种英语
WOS记录号WOS:000338878100002
项目编号30971292 ; 30725038 ; 7122193 ; 2011AA020105
资助机构National Natural Science Foundation of China ; Natural Science Foundation of Beijing ; National High Technology Research and Development Program of China (Program 863) ; Clinical Subject&prime ; s Key Project of the Ministry of Health
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53523
专题北京大学第二临床医学院
作者单位1.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
2.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
3.Peking Univ, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chang, Y-J,Huang, X-J. Haploidentical SCT: the mechanisms underlying the crossing of HLA barriers[J]. BONE MARROW TRANSPLANTATION,2014,49(7):873-879.
APA Chang, Y-J,&Huang, X-J.(2014).Haploidentical SCT: the mechanisms underlying the crossing of HLA barriers.BONE MARROW TRANSPLANTATION,49(7),873-879.
MLA Chang, Y-J,et al."Haploidentical SCT: the mechanisms underlying the crossing of HLA barriers".BONE MARROW TRANSPLANTATION 49.7(2014):873-879.
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