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Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by gastroesophageal reflux
Zhao Yu-hao2; Liu Zhao-lan3; Li Lan-hua4; Jiang Sheng-hua; Shi Cheng-he1
关键词Tcm Bronchial Asthma Gastroesophageal Reflux Comparison Of Curative Effects
刊名JOURNAL OF TRADITIONAL CHINESE MEDICINE
2012-03-01
32期:1页:12-18
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者Capital Special Project Grant for Traditional Chinese Medicine and Nursing Research ; Capital Special Project Grant for Traditional Chinese Medicine and Nursing Research
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]DISEASE
英文摘要

OBJECTIVE: To assess the effectiveness and safety of Traditional Chinese Medicine (TCM) treatment of non-acute bronchial asthma complicated by gastroesophageal reflux.

METHODS: We searched databases from MEDLINE, Cochrane Library, CNKI, VIP, CBM, Wanfang Data, and TCM Database Systems. All randomized, controlled trials (RTCs) of TCM treatment of non-acute asthma complicated by gastroesophageal reflux were included. Data were independently collected by two reviewers. The standards for assessing quality described in the Cochrane Handbook for Systematic Reviews of Interventions were used to evaluate articles. Meta-analyses were conducted using Rev-Man 5.0.17 software. Heterogeneity was assessed, and a corresponding effects model was used to merge and analyze results. Indexes used to evaluate curative effects were: clinical efficacy, symptom scores, pulmonary function values, and adverse incidents. Effectiveness was indicated using risk ratio (RR) or mean difference (MD), and 95% confidence intervals (Cls) were calculated.

RESULTS: Six RCTs were included, involving 304 patients with non-acute asthma complicated by gastroesophageal reflux. The treatment groups received Chinese drugs alone or TCM combined with standard Western medical treatment, and the control groups received standard western medical treatment alone. Standard Western medical treatment included anti-inflammatory drugs and born-chodilators for ashtma, and drugs to promote gastric peristalsis and inhibit gastric acid production for gastroesophageal reflux. Methodological quality was low in all six RCTs. Two RCTs showed that clinical efficacy was higher in the treatment group than in the control group(RR: 1.43, 95%CI: 1.10 to 1.87 vs RR: 1.51, 95%CI: 1.09 to 2.08). One RCT showed that the asthma score was lowered more effectively in the treatment group than in the control group (MD: -1.10, 95%CI: -2.04 to -0.16). Two RCTs showed that the gastroesophageal reflux score was reduced more effectively in the treatment group than in the control group (RR: -3.70,95% CI-4.30 to 3.10 vs RR: -5.30, 95% CI: -6.32 to -4.28). One RCT showed that some pulmonary function values were improved more effectively in the treatment group than in the control (P<0.05). No differences were seen in the various indexes between groups in the other RCTs. No adverse reactions, dropout rates,or follow-up rates were reported in any of the RCTs.

CONCLUSIONS: The clinical symptoms of non-acute asthma complicated by gastroesophageal reflux can be improved by some Chinese drugs. Curative effects can be increased by combining the use of TCM with Western medicine. Because of the small quantity and low quality of research reported to date, it is necessary to conduct further RCTs to confirm these results. The results of this systematic review indicate that the quality of future clinical trials should be improved by including larger patient numbers, correctly randomizing patients into study groups, using blinding methods to measure and assess outcomes, and using accepted indexes to evaluate curative effects. (C) 2012 JTCM. All rights reserved.

语种英语
所属项目编号ZM01
资助者Capital Special Project Grant for Traditional Chinese Medicine and Nursing Research ; Capital Special Project Grant for Traditional Chinese Medicine and Nursing Research
WOS记录号WOS:000301321000003
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/53527
专题北京大学第三临床医学院
作者单位1.Beijing Univ, Hosp 3, TCM Dept, Beijing 100191, Peoples R China
2.Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China
3.Beijing Univ Chinese Med, Ctr Evidence Based Chinese Med, Beijing 100029, Peoples R China
4.Weifang Med Coll, Sch Publ Hlth, Weifang 261042, Shandong, Peoples R China
推荐引用方式
GB/T 7714
Zhao Yu-hao,Liu Zhao-lan,Li Lan-hua,et al. Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by gastroesophageal reflux[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2012,32(1):12-18.
APA Zhao Yu-hao,Liu Zhao-lan,Li Lan-hua,Jiang Sheng-hua,&Shi Cheng-he.(2012).Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by gastroesophageal reflux.JOURNAL OF TRADITIONAL CHINESE MEDICINE,32(1),12-18.
MLA Zhao Yu-hao,et al."Systematic review of randomized controlled trials of traditional Chinese medicine treatment of non-acute bronchial asthma complicated by gastroesophageal reflux".JOURNAL OF TRADITIONAL CHINESE MEDICINE 32.1(2012):12-18.
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